

Get in the KNOW
on LA Startups & Tech
X
Image by BOKEH STOCK/ Shutterstock
Southern California Grows Roots as Potential Hotspot For Hair Loss Therapies
David Shultz
David Shultz reports on clean technology and electric vehicles, among other industries, for dot.LA. His writing has appeared in The Atlantic, Outside, Nautilus and many other publications.
Ah Southern California, the land of movie stars, glamor, and beauty. A paradise of botox, silicone, and saline. A perfect incubator for a cure for baldness. Maybe.
Several new scientific studies have cropped up in recent months with tantalizing results that suggest researchers are narrowing in on the mechanism that makes hair start growing. At UC Irvine, Maksim Plikus’s research showed that a molecule called SCUBE3 can stimulate new hair growth in mice when injected into the skin. An hour north, at UC Riverside, complementary research by Qixuan Wang is delving into the same mechanics.
Both groups are focusing on a receptor in hair follicle cells called TGF-β, which plays several roles in virtually every tissue in the body. Critically, the receptor is involved in deciding when cells divide and die. By stimulating these proteins correctly–with the right molecules, in the right concentrations, at the right time–researchers are beginning to reactivate dormant hair follicles in mice.
These therapies have a long road ahead of them before they’re available in your local pharmacy. But that hasn’t stopped Plikus from co-founding Amplifica Holdings group with the intent of doing just that. Any treatment using SCUBE3 is probably 2-3 years away from human trials, but the company has other hair-loss therapy compounds in the pipeline that might be ready for human trials sometime next year, says CEO Frank Fazio. Amplifica is keeping its cards extremely close to the vest for now, and wouldn’t say anything about what type of molecule they’re using or how it works. Fazio would only say that the company is “laser-focused” on hair loss.
“We have two compounds that are going to be studied with the hopeful intent of actually having an impact on hair growth and hair restoration,” he said. More information should be available soon, however: Fazio says Plikus has new research that’s under review in “a prestigious journal” which should give some insight into what Amplifica is targeting with these first drugs.
The company is in the process of raising a $10 million Series A to get operations off the ground and transition it out of research and development and into clinical trials. In addition to potentially treating disorders like alopecia areata and regrowing hair in scar tissue, Plikus estimates that the hair loss market could be worth $12 billion by 2025.
There are several existing drugs on the market already, but they come with long term side effects and aren’t universally effective. Ninety percent of new drugs fail in clinical trials, but if Amplifica succeeds, the drugs could be life-changing and the return on investment massive.
From Your Site Articles
- Meet 3 Early Stage Science Startups at First Look's Showcase - dot.LA ›
- An Early Peek at First Look's Showcase of Cutting-Edge Science ... ›
- Biotech in Los Angeles Might Soon Get Its Own Bioscience Hub - dot ... ›
- Los Angeles Biotech News - dot.LA ›
- LA Tech Raises: Griffin Capital Raises $4.9M Third Round - dot.LA ›
- Julian Addo On Leaving Corporate To Start Adowa Beauty - dot.LA ›
Related Articles Around the Web
David Shultz
David Shultz reports on clean technology and electric vehicles, among other industries, for dot.LA. His writing has appeared in The Atlantic, Outside, Nautilus and many other publications.
Menlo Microsystems Raises $150 Million to Build Smaller, Smarter Electronic Switches
01:00 PM | March 09, 2022
Image courtesy of Menlo Microsystems
Sign up for dot.LA’s daily newsletter for the latest news on Southern California’s tech, startup and venture capital scene.
Menlo Microsystems, an Irvine-based maker of electronic switches, has raised $150 million in new funding as it looks to expand its domestic manufacturing capabilities, the company announced Wednesday.
The Series C round was led by Palo Alto-based Vertical Venture Partners and Paris-based Future Shape, which is headed by Apple alum (and iPod and iPhone co-inventor) Tony Fadell. Fidelity, DBL Partners and Adage Capital Management were also new investors in the round, which takes Menlo Micro’s total funding to $225 million.
Menlo Micro's Ideal Switch.
Image courtesy of Menlo Micro
The cornerstone of Menlo Micro’s business is its patented Ideal Switch: a smart device component that can divert an electrical circuit from one conductor to another and can be used in everything from lights and computer keyboards to fans and thermostats. The company pitches the Ideal Switch as enabling circuits to be 100 times smaller and 100 times more efficient across industries including medicine, aerospace and defense, telecommunications and consumer electronics.
While switches may not seem like the most exciting solution to our current energy crisis, their collective power could be a huge disruptor to the energy market. If the 1 billion ceiling fans used worldwide swapped their existing controllers with an Ideal Switch, according to company's marketing materials, it would save enough energy to take 17 power plants off the grid.
Menlo Micro also cites a study by Adroit Market Research that underscores the need for a switch swap. “The global electrification market is experiencing tremendous growth, projected to reach $128 billion by 2028,” according to Dallas-based Adroit. If the Ideal Switch were to replace all of the world’s aging electrical relay technology, all industrial processes could save a total of $7 trillion in operating costs by 2050, Adroit stated.
Menlo Micro CEO Russ Garcia.Image courtesy of Menlo Micro
Menlo Micro CEO Russ Garcia said the new funding “will enable us to expand our manufacturing in the U.S. and accelerate the development of our power roadmap to solve some of the world’s most pressing challenges.”
Formed in 2016 after being spun off from GE Ventures (the venture capital arm of General Electric), Menlo Micro plans to scale up its manufacturing in the not-too-distant future. The company said it is exploring possible manufacturing locations in California, New York, Texas and Florida, but has not disclosed a timeline for selecting a manufacturing site.
Read moreShow less
Pat Maio
Pat Maio has held various reporting and editorial management positions over the past 25 years, having specialized in business and government reporting. He has held reporting jobs with the San Diego Union-Tribune, Orange County Register, Dow Jones News and other newspapers in Ohio, West Virginia, Maryland and Washington, D.C.
FaZe Clan is Finally Embracing Women’s Esports Over a Decade After its Founding
05:05 AM | March 15, 2023
Photo: FaZe Clan
FaZe Clan signed its first all-female esports team last week, and the five-woman team will begin competing this year in a spinoff of Riot Games’ “Valorant” pro league.
This is the first all-female esports team FaZe’s invested in since its 2010 launch. Before signing with FaZe, the five pro players – Jennifer “refinnej” Le, Emma “emy” Choe, Vannesa Emely “panini” Emory, Madison “maddiesuun” Mann and Diane “di^” Tran – first became teammates while competing in Riot’s “Valorant” North American Champions Tour last year under the team name Hamboigas.
The fivesome won’t compete in the pro “Valorant” league since that’s all-men. But they will make their debut as a FaZe team this year competing in a spinoff of the league called “VCT Game Changers,” which was created last February by Riot Games to offer new opportunities for “women and other marginalized genders” in its esports community. The esports industry largely still has yet to embrace co-ed esports at a professional level, though many collegiate programs under the National Association of College Esports do. This has led some esports fans to wrongly speculate that it’s just a skill issue and that female pros just aren’t good enough to play on pro teams.
Erik Anderson, FaZe’s head of esports since 2016, said the organization went “out of our way” to make it clear in the announcements that this was a FaZe team just like its other all-male ones. Anderson said FaZe tried to make it clear in the branding that the all-women team didn’t seem like “some other sub-brand… they’re part of FaZe Clan, it’s not some sort of spin-off.”
Anderson wouldn’t directly say why FaZe waited so long to sign female pros, but claimed it was partly waiting for the right opportunity. Anderson noted “Game Changers itself is a pretty new structure,” having launched in 2021.
But Anderson hopes Riot will continue to update “Valorant,” adding he hopes to see it move into collegiate competitions which could further democratize its player base and encourage new women to consider becoming pros at it.
Prior to signing the quintet, FaZe had one other female gamer on staff, a content creator named Kalei Renay who joined in 2021 and boasts over half a million followers on Twitch. But until now, the organization that’s nearing its 13th birthday has remained largely male-dominated.
Still, FaZe figured that it was better late than never to diversify its ranks. All five players are represented by the same agent, who pitched them as a package deal to various esports outfits looking to recruit more women. Each player wouldn’t disclose contract terms but Emory told dot.LA “FaZe pays us very well, and compared to my last contracts it's technically been more or [about] the same.”
The company’s staring down the barrel of a potential stock delisting, having seen over 95% of its value wiped out since its $725 million IPO last August. Still, its audience remains loyal and demanding new content. “We got a great response from our community” about the all-female team, Anderson said.
Tran added however that she’s optimistic that this team can help change how gaming treats female pros, and noted that over the years as esports has grown in popularity, the acceptance of women in the field has too. “You do face discrimination no matter what in gaming, just because it’s a male-dominated area,” Tran said. “But I do think it’s gotten better and now to be competing as [a] female, I don’t think it's actually as bad as you would think.”
Emory, who splits her time between the Bay Area and Los Angeles, agreed. “Now on ‘Valorant’ you can't type certain things and you just get chat banned,” she said. Adding that, “moderation has gotten so much better. People just get banned left and right, there’s certain words you can’t even type anymore. I think Riot’s doing a really good job… and I’d say the moderation has gotten a lot better, because in other games you really didn’t really have that luxury.”
From Your Site Articles
- 'No Matter What I’m Doing, It's Always Controversial': Cloud9's All-Women Esports Team Talks Sexism in Gaming ›
- After Ten Years, Gaming Giant FaZe Clan Has No Plans to Grow Up, But Big Ambitions to Dominate ›
- Why FaZe Clan is Expanding its Partnership With the NFL ›
- LA Tech ‘Moves’: FaZe Clan Boosts Its Leadership Team With New Hires ›
- The Future of NRG Esports Is in Madison Square Garden - dot.LA ›
- LA Tech Week: Normalizing Esports Investment Downturns - dot.LA ›
Related Articles Around the Web
Read moreShow less
Samson Amore
Samson Amore is a reporter for dot.LA. He holds a degree in journalism from Emerson College. Send tips or pitches to samsonamore@dot.la and find him on Twitter @Samsonamore.
https://twitter.com/samsonamore
samsonamore@dot.la
RELATEDTRENDING
LA TECH JOBS