The California Institute of Technology ranks as one of the top universities in the world when it comes to receiving patents. But more of those inventions should successfully be making it to market, at least according to the investment thesis of Freeflow, a new pre-seed and seed stage venture firm that exclusively backs Caltech startups focused on human and planetary health.

"The people there are amazing scientists who are not afraid to tackle the hard problems," said Freeflow founder and managing partner David Fleck, who was an early Google employee who has spent the last 20 years tackling big data. "But as I started to spend more time there I realized the ecosystem was somewhat underdeveloped. They needed investors that could help them with capital and help them develop a company."

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Nate Cavanaugh has a penchant for prophecy. The 24-year-old founder of Venice-based Brainbase wrote a letter to his future self when he was 13 in which he presciently asked, "Do you still want to start your own computer company?" At 18, in a high school assignment describing his role model, he chose Mark Zuckerberg, and proclaimed that "I, too, plan on starting my own technology company in college... (and) plan to drop out of college once I can comfortably support myself."

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As a veteran of the Marine Corps who served as an infantry officer in Iraq and Afghanistan in the years after 9/11, Dan Burton saw drone technology, quite literally, take off.

Drones went from needing 55 people to fly, to as few as three pilots, to just one. Meanwhile, soldiers on the ground were thrilled to have a decentralized way to get dedicated eyes from above on missions.

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