Can Venture Capital Help Unlock 'Underdeveloped' Caltech?

Ben Bergman

Ben Bergman is the newsroom's senior finance reporter. Previously he was a senior business reporter and host at KPCC, a senior producer at Gimlet Media, a producer at NPR's Morning Edition, and produced two investigative documentaries for KCET. He has been a frequent on-air contributor to business coverage on NPR and Marketplace and has written for The New York Times and Columbia Journalism Review. Ben was a 2017-2018 Knight-Bagehot Fellow in Economic and Business Journalism at Columbia Business School. In his free time, he enjoys skiing, playing poker, and cheering on The Seattle Seahawks.

Can Venture Capital Help Unlock 'Underdeveloped' Caltech?

The California Institute of Technology ranks as one of the top universities in the world when it comes to receiving patents. But more of those inventions should successfully be making it to market, at least according to the investment thesis of Freeflow, a new pre-seed and seed stage venture firm that exclusively backs Caltech startups focused on human and planetary health.

"The people there are amazing scientists who are not afraid to tackle the hard problems," said Freeflow founder and managing partner David Fleck, who was an early Google employee who has spent the last 20 years tackling big data. "But as I started to spend more time there I realized the ecosystem was somewhat underdeveloped. They needed investors that could help them with capital and help them develop a company."


Fleck wants to be that investor. "We're the only one that we know of having this approach," he added.

David Fleck, who started Freeflow after he sold his online commenting service, Disqus, for a reported $90 million in 2017, hopes to broaden the perception of Los Angeles from a consumer tech hub to a place with the sorts of deep tech companies more commonly associated with where he spent most of his career, Silicon Valley.

Fleck, who started Freeflow after he sold his online commenting service, Disqus, for a reported $90 million in 2017, hopes to broaden the perception of Los Angeles from a consumer tech hub to a place with the sorts of deep tech companies more commonly associated with where he spent most of his career, Silicon Valley. He believes most L.A. VC firms, clustered in Santa Monica, neglect what they view as the hinterlands of Pasadena, where Caltech is based.

"It's very hard to go from west to east," Fleck said. "We made a conscious decision to say we are a Pasadena firm."

Freeflow has raised $8 million of capital so far and is aiming to close a $30 million fund by the end of the year with the help of the heavy hitters on its advisory board who are also serving as limited partners; Fred Wilson, founder of Union Square Ventures, Chris Farmer founder of SignalFire, and Chris Douvos, founder of Ahoy Capital.

Wilson, an early investor in Twitter, Tumblr and Etsy, is based in New York but spends several months every winter in L.A. "He became a good friend and mentor and encouraged us to go after the thesis," Fleck said.

Freeflow is fully independent of Caltech. That differs from the approach of the Massachusetts Institute of Technology, which launched its own venture fund as a public benefit corporation in 2016, The Engine, focusing on "tough tech." Stanford University backed an accelerator starting in 2013, StartX, though the university ended funding last year.

Caltech has had some notable success. Earlier this year, a federal jury in Los Angeles ruled Apple owed Caltech $837 million for selling WiFi chips that infringed on the school's patents and Broadcom, which sold the chips to Apple, owed Caltech another $270 million. (The companies are planning to appeal.)

Freeflow is aiming to back 20 startups over the next 18 months with check sizes averaging around half a million dollars and recently announced its first four investments:

  • Appia Bio: Developing a stem cell therapy platform for the development of new drugs to treat cancer, which was initially developed in the Caltech lab of professor and Nobel laureate Dr. David Baltimore.
  • Entos: Making physics-based machine learning software that maps chemical space to discover promising new molecules for therapeutics, vaccines and diagnostics through a SaaS model.
  • Molecular Instruments: Designs and synthesizes kits for quantitative bio-imaging in drug development, clinical pathology and diagnostics and academic research.
    • Toofon: Developing an autonomous, heavy lift drone for last-mile delivery and emergency response, which came out of Caltech's Center for Autonomous Systems and Technologies (CAST).
    https://twitter.com/thebenbergman
    ben@dot.la

    Subscribe to our newsletter to catch every headline.

    Office Hours: Apex Founder Ian Cinnamon on Why LA Is the Aerospace Capital of the World

    Spencer Rascoff

    Spencer Rascoff serves as executive chairman of dot.LA. He is an entrepreneur and company leader who co-founded Zillow, Hotwire, dot.LA, Pacaso and Supernova, and who served as Zillow's CEO for a decade. During Spencer's time as CEO, Zillow won dozens of "best places to work" awards as it grew to over 4,500 employees, $3 billion in revenue, and $10 billion in market capitalization. Prior to Zillow, Spencer co-founded and was VP Corporate Development of Hotwire, which was sold to Expedia for $685 million in 2003. Through his startup studio and venture capital firm, 75 & Sunny, Spencer is an active angel investor in over 100 companies and is incubating several more.

    ​Ian Cinnamon
    Ian Cinnamon

    On this episode of Office Hours, Apex founder and CEO Ian Cinnamon discusses the importance of investing in space exploration and shares his thoughts on the evolving space ecosystem in Los Angeles.


    Read moreShow less
    https://twitter.com/spencerrascoff
    https://www.linkedin.com/in/spencerrascoff/
    admin@dot.la

    This Week in ‘Raises’: Measurabl Snags $93M, Selva Ventures Grabs $34M

    Decerry Donato

    Decerry Donato is a reporter at dot.LA. Prior to that, she was an editorial fellow at the company. Decerry received her bachelor's degree in literary journalism from the University of California, Irvine. She continues to write stories to inform the community about issues or events that take place in the L.A. area. On the weekends, she can be found hiking in the Angeles National forest or sifting through racks at your local thrift store.

    Raises
    Image by Joshua Letona

    A local data management platform company lands fresh funding to help commercial real estate owners reduce carbon footprint, while one Los Angeles-based venture firm closes its second fund to accelerate the growth of emerging companies across health, wellness, beauty and personal care.

    ***

    Read moreShow less

    McKinsey & Company Launches InLA Accelerator To Help Underrepresented Founders Tackle Startup Challenges

    Decerry Donato

    Decerry Donato is a reporter at dot.LA. Prior to that, she was an editorial fellow at the company. Decerry received her bachelor's degree in literary journalism from the University of California, Irvine. She continues to write stories to inform the community about issues or events that take place in the L.A. area. On the weekends, she can be found hiking in the Angeles National forest or sifting through racks at your local thrift store.

    McKinsey & Company Launches InLA Accelerator To Help Underrepresented Founders Tackle Startup Challenges
    InLA

    In 2022, female founders saw a 28% decline in overall U.S. funding, while Black-led startups saw a 38% decline in total capital received. In an effort to increase funding for minority-led startups, global venture firm McKinsey & Company is launching InLA, an accelerator program for underrepresented founders.

    “This effort is something that the firm has been really excited about for a long time,” Engagement Manager Elkhyn Rivas Rodriguez said. “There's obviously a meaningful and growing startup community out here and just from a diversity standpoint, LA is incredibly diverse and multi-ethnic and multicultural. So we think that there will be a really great pool of potential companies to partner with.”

    Read moreShow less
    RELATEDEDITOR'S PICKS
    LA TECH JOBS
    interchangeLA
    Trending