Appia Bio Comes Out of Stealth Aiming to Offer Faster, Safer Cancer-Fighting Therapies

Keerthi Vedantam

Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.

Appia Bio Comes Out of Stealth Aiming to Offer Faster, Safer Cancer-Fighting Therapies

Cell therapy has taken the oncology world by storm.

For cancer patients who have tried every other treatment, cell therapies not only have the potential to kill cancer cells in the moment, but they can multiply and continue bolstering the immune system in the future. But the treatment — often used only as a last resort — is expensive, time-consuming and potentially fatal.

Appia Bio, a Westwood-based biotech startup that came out of stealth on Tuesday, hopes to speed up the process with a new type of treatment known as allogeneic cell therapies. The company is armed with $52 million in Series A funding led by venture capital firm 8VC.


The therapy is not yet targeted towards a specific cancer, but could have major impacts for oncology as a whole.

"One of the advantages is it's immediately available because a lot of these patients are actually quite sick. They can't really wait two weeks," said Appia Bio CEO JJ Kang.

Currently on the market are autologous (not allogeneic) cell therapies, or CAR-T therapies, that take a patient's white blood cells, reengineer them to eliminate cancer cells, and inject them back into the patient. The process usually takes two weeks. Kite Pharma, an early player in CAR-T therapies, received FDA approval for two therapies to treat certain lymphomas, and other big names like Amgen and Novartis have thrown their hats in the ring as well.

Appia Bio CEO JJ Kang

Appia Bio CEO JJ Kang

But there are financial barriers — one of Kite Pharma's therapies has a sticker price of over $373,000 for a one-time treatment. And the window in which these made-to-order therapies work is small — patients can only access CAR-T therapies after exhausting other every possible option, and by that time their organs may be too weak to properly benefit from cell therapy.

Appia Bio thinks it can offer faster, safer allogeneic cell therapies at scale using a patented platform created in a lab run by Dr. Lili Yang, an associate professor at UCLA.

The allogeneic cell therapy takes the white blood cells of others, instead of the patient's. It's not a smooth process — there's the dangerous possibility a cancer patient's immune system will detect the foreign cells as threatening, and fight against them. But the allogeneic process could net off-the-shelf results, potentially allowing people to get the treatment they need immediately.

"In some ways you can think of cells as these little integrative robots or machines...," Kang said. "And so, when done in the best way, it would recognize whatever it is that you wanted to do and then have a very finely tuned response to it that can potentially have better efficacy."

Appia's platform, ACUA (Appia Cells Utilized for Allogeneic), generates often hard-to-find iNKT-cells from hematopoietic stem cells to create the therapy. Appia hopes that using iNKT cells will trick patients' immune systems so their bodies will be less likely to attack the foreign specimens.

"They all have risks associated with them," Dr. Eunjoo Pacifici, a professor at the USC School of Pharmacy, said. "But the potential benefits of these products is so significant that the FDA looks for ways to allow these products to be on the market but in a very strictly managed way so that the risk is managed."

Appia Bio isn't the only one trying to create bulk cell therapies. Caribou Biosciences announced in March it had $115 million to develop allogeneic cell therapies, and Poseida Therapeutics is working on a slew of allogeneic cell therapies as well.

"Cell therapy has delivered really durable efficacy for the subset of patients that it works for," Kang said. "It's really been transformative as far as its kind of curative potential."

Editor's note: This story has been updated to clarify ACUA's functions.

https://twitter.com/KeerthiVedantam
keerthi@dot.la
LA Tech Week 2025: Sunday’s Event Lineup

Here's the Sunday, October 19th lineup for LA Tech Week 2025, organized by location so you can easily explore events that fit your goals and schedule. Dive in and see what’s happening near you!

ARTS DISTRICT

3:00 PM

BEL AIR

3:00 PM – 7:00 PM

BURBANK

6:30 PM – 9:30 PM

CULVER CITY

9:00 AM – 5:00 PM

4:30 PM – 7:30 PM

INGLEWOOD

10:00 AM – 2:00 PM

  • Spinovation: The Future Is Femme, The Future is Frequency: See Details Here
    Sonder Impact, Black Women Spin, Sip & Sonder

KOREATOWN

12:00 PM – 3:00 PM

MARINA DEL REY

12:00 PM

  • Sunday Tech Brunch
    Sawubona

MID CITY

9:00 AM – 11:00 AM

  • Women in Cleantech Hike and Network: See Details Here
    Women in Cleantech and Sustainability

SANTA MONICA

9:00 AM

10:00 AM

3:45 PM

4:00 PM – 7:30 PM

  • OFF THE HOOK Santa Monica Seafood Festival: See Details Here
    Spin PR Group, City of Santa Monica, Tech St.

6:00 PM

7:00 PM

  • Pritam: A Musical Legend - Live in Concert: See Details Here
    American South Asian Network

7:00 PM

  • Building AI workflow editor in React with Workflow Builder SDK: See Details Here
    Workflow Builder

7:00 PM

8:00 PM

  • Unlock Apple's Corporate Advantage for your Startup!: See Details Here
    iStore by St. Moritz

TOPANGA CANYON

3:00 PM

  • Dreamore Hike and Picnic: LA Tech Week: *Invite Only*
    Dreamore

VENICE

10:00 AM – 12:00 PM

  • Coffee, Walk, and Schmooze: See Details Here
    JFE (Jews For Entrepreneurship) Network

VIRTUAL (LA)

10:00 AM

  • Level Up with LinkedIn: A Student’s Guide to Networking & Opportunities (Virtual Event): See Details Here
    FIMAC

10:00 AM

WEST ADAMS

1:00 PM – 3:00 PM

For updates or more event information, visit the official Tech Week calendar.

Enjoy LA Tech Week 2025!

Download the dot.LA App


LA Tech Week 2025: Saturday’s Event Lineup

Here's the Saturday, October 18th lineup for LA Tech Week 2025, organized by location so you can easily explore events that fit your goals and schedule. Dive in and see what’s happening near you!

BEVERLY HILLS

2:00 PM

CENTURY CITY

7:00 PM – 10:00 PM

CULVER CITY

9:00 AM – 5:00 PM

10:00 AM – 11:30 AM

1:00 PM

DTLA

7:00 PM

  • {MiniMax x Nakid x SkyPortalx}: TECH/MOTION/MUSIC/ART: See Details Here
    MiniMax (Hailuo AI)

10:00 PM – 2:00 AM

EL SEGUNDO

10:00 AM

  • Venture on the Green: *Invite Only*
    BLCK VC

4:00 PM

INGLEWOOD

7:00 PM

  • Valar Atomics, Durin and Discipulus Ventures - Night With A Nuclear Reactor: See Details Here
    Valar Atomics, Durin, Discipulus Ventures

MARINA DEL REY

8:30 AM

12:00 PM – 3:00 PM

5:00 PM

  • LOST iN Sunset Sail: Navigating the Tides of the Creator Economy & Media: See Details Here
    LOST iN

PASADENA

9:00 AM

PLAYA VISTA

2:00 PM – 4:00 PM

SANTA MONICA

7:00 AM

9:00 AM

  • Pedal & Network: Tech Cyclists @ LA Tech Week 🚵: See Details Here
    Instafill.ai

9:30 AM

  • Getty Center Guided Tour & (Optional) Photography Scavenger Hunt: See Details Here
    NEW MOON Impact Productions

10:30 AM – 11:30 AM

11:00 AM – 2:15 PM

12:00 PM – 5:00 PM

1:00 PM – 5:00 PM

1:30 PM

  • Self-Defense in Court and the Streets: See Details Here
    Santa Monica Striking, Luri Inc.

2:00 PM

  • SMARTUP 500: THE FIRST AT TECH WEEK LA - Launching the world’s first Startup Ranking: See Details Here
    Smart Times

2:00 PM

  • NLPs (No Lame Panels) The Creator X Founder Rooftop Party: See Details Here
    Startup Village, Sanctuary

3:00 PM – 4:00 PM

4:00 PM – 6:30 PM

  • Just Do It?: Helping Founders Perform Like Olympians: See Details Here
    Elite Psychology Group

5:00 PM

6:00 PM

6:00 PM – 9:00 PM

6:00 PM

6:00 PM – 9:00 PM

  • The Future of Hospitality: Poetry, Provenance & Passports: See Details Here
    Villa Kitchen, Airble, We Speak Dance, Techstars San Francisco

7:00 PM

  • 🚀 Investor x Founder Open Mic Pitches: See Details Here
    Feathr, Los Angeles Fun Events

7:00 PM

  • Life is a Pitch - LA Edition: *Invite Only*
    DeepMyst

TOPANGA CANYON

5:00 PM – 8:30 PM

  • Walk&Jam: Use AI to make art while hiking Topanga Canyon: See Details Here
    Formhaus llc, Wonderland Immersive Design

TORRANCE

1:00 PM – 4:00 PM

  • Crunches & Conversations Presented by The Differentials and KIS Training Studios: See Details Here
    The Differentials, KIS Training Studios

VENICE

1:00 PM – 4:30 PM

  • Beyond the Language Barrier: Exploring AI's Next Frontier: See Details Here
    Medusa AI

VENICE BEACH

8:00 AM – 12:00 PM

  • SŨRFED Club @ Venice Beach: Founders, Creators, Investors share the waves: See Details Here
    SŨRFED Club, Go Vitamins

WEST ADAMS

9:30 AM – 10:45 AM

  • Funders Shaping Democracy, AI & Media: See Details Here
    New Media Ventures, New Rising Ventures

WEST HOLLYWOOD

4:00 PM

6:00 PM – 8:00 PM

9:30 PM

  • Vibe Check Comedy Show, Tech Week Edition! @ Hollywood Improv: See Details Here
    Vibe Check Comedy

For updates or more event information, visit the official Tech Week calendar.

Enjoy LA Tech Week 2025!

Download the dot.LA App


LA Tech Week 2025: Friday’s Event Lineup

Here's the Friday, October 17th lineup for LA Tech Week 2025, organized by location so you can easily explore events that fit your goals and schedule. Dive in and see what’s happening near you!

ARTS DISTRICT

8:30 AM – 12:00 PM

  • Power Day: Ideas, Pitches, Connections: See Details Here
    Los Angeles Cleantech Incubator (LACI)

6:00 PM

  • WEB3 GAMING IS DEAD - Happy Hour: See Details Here
    Plassa Capital, Yee-Haw Monster Trucks

BEVERLY HILLS

10:00 AM – 11:00 AM

1:00 PM – 2:00 PM

2:00 PM – 3:00 PM

3:00 PM – 4:00 PM

4:00 PM

6:00 PM – 9:00 PM

  • So you went viral, Now what? (pt II): See Details Here
    Verci, Study Fetch, TechSpace

8:00 PM

  • Private Pool: GP x LP x FO: *Invite Only*
    Visionlist Commons , Bay Area Innovest

BRENTWOOD

8:00 AM

  • Founders & Investors Hike: See Details Here
    Salehpour Legal, Technology Founders of America

CARSON

11:45 AM

  • Lightspeed x SVB Porsche Experience: *Invite Only*
    Lightspeed Venture Partners, SVB

CULVER CITY

8:00 AM – 6:00 PM

11:00 AM

1:00 PM

  • Surf Parks & Wave Pools: From Doja Cat to Mark Zuckerberg: See Details Here
    Surflytics

8:00 PM – 12:00 AM

EL SEGUNDO

11:30 AM – 2:00 PM

5:00 PM – 8:00 PM

HOLLYWOOD

10:00 AM

  • AI, Revenue, and Reality: How Fortune 500s Work With Startups That Ship: See Details Here
    Sunrise AI, OpenTable

12:00 PM – 2:00 PM

  • Unplugged: LA Tech Week Recharge Experience with TAY × Checked Out: See Details Here
    TAY Fitness, Checked Out

9:00 PM

INGLEWOOD

8:00 AM

  • TCSI Presents: Caffeine & Connections: See Details Here
    The Cyber Security Intellects Nonprofit

LONG BEACH

7:00 AM

MALIBU

10:00 AM

  • Great Leaders Podcast & Profiles: See Details Here
    NEW MOON Impact Productions, Origin Studios

12:30 PM

MARINA DEL REY

9:00 AM

  • Keeping Your Freedom as a Founder: Real Talk on Funding: See Details Here
    Lighter Capital

10:00 AM – 1:00 PM

  • D-Wave Research Day & Hackathon!: See Details Here
    USC Information Sciences Institute, D-Wave

4:00 PM – 6:00 PM

  • The Sky is Not the Limit: All About Aerospace: See Details Here
    Sunstone Management, USC Viterbi Startup Garage

PASADENA

10:00 AM – 1:00 PM

11:30 AM – 1:30 PM

  • Deep Tech Entrepreneurship Pillars of Pasadena Tech: See Details Here
    Innovate Pasadena, Pasadena SBDC, City of Pasadena

PLAYA VISTA

9:00 AM

12:00 PM – 2:00 PM

  • Vision to Venture - AI Media Showcase powered by Google AI: See Details Here
    Google

SANTA MONICA

7:00 AM – 8:30 AM

  • Signal Run : RTC x Wildwood VC: See Details Here
    Run Tech Club, Wildwood Ventures

7:30 AM

8:45 AM – 10:45 AM

9:00 AM – 11:00 AM

  • Slash Burn Rates & Scale Your Startup: See Details Here
    Arizona Commerce Authority (ACA)

9:00 AM

  • Driving a Digital Ecology Relay: What is at Stake: See Details Here
    The PORT GLOBAL, GLOBAL PORTAL INSTITUTE

9:30 AM – 11:30 AM

10:00 AM – 1:00 PM

  • The Enduring Value of Inclusive Capital: See Details Here
    Founders Registry. Nervana

10:00 AM – 12:00 PM

10:30 AM

11:30 AM – 1:00 PM

  • Advisors to Investors Lunch: Venture Capital for enterprise leaders: See Details Here
    Collinear Capital, Worlds

12:00 PM

  • Powerhouse Capital & a16z speedrun Investor Lunch Mixer: See Details Here
    Powerhouse Capital, a16z, speedrun

2:00 PM

  • Where Robotics Meets Heart - Embedding Family Values in a Future with AI: See Details Here
    Trove, Puerto Rico Blockchain Association, MindfulBytes

2:00 PM

3:00 PM

3:00 PM

3:00 PM

  • Workshop: Create An Enterprise Chatbot and Unlock the 70% of Data Data You’re Not Using: See Details Here
    Aparavi

4:00 PM

5:00 PM – 10:00 PM

5:30 PM

5:30 PM – 9:30 PM

6:00 PM – 8:30 PM

  • USC Alumni Founders & Investors: See Details Here
    USC Alumni Entrepreneurship Network, Techstars

6:00 PM

  • Social Currency Series/Greenlit presents PitchPop: See Details Here
    Social Currency Series, Greenlit

6:00 PM – 9:00 PM

6:30 PM

6:30 PM – 10:00 PM

6:30 PM

  • Lets get the LA Bioeconomy brewing: See Details Here
    Founders, Friends & Fermentation, Saku Biosciences

7:00 PM – 11:30 PM

7:00 PM – 10:00 PM

7:00 PM – 10:00 PM

7:00 PM

7:00 PM

  • Liquid Equity 2: The Premiere Gathering for Founders, Creator
    Coeus Collective

7:00 PM

7:00 PM

  • For the Love of Tech | Speed Dating for Tech Professionals: See Details Here
    Feathr, Los Angeles Fun Events

7:00 PM

SOUTH LA

3:00 PM

TORRANCE

9:00 AM – 11:00 AM

  • The Future of Space & Security Panel: See Details Here
    Northwood Space, Anduril Industries, Impulse Space, Astranis

VENICE

9:00 AM – 10:45 AM

9:00 AM – 11:30 AM

11:00 AM

11:30 AM – 2:30 PM

12:30 PM

  • Creative Partners: Human + AI Storytelling: See Details Here
    Othelia, Primordial Soup

2:00 PM – 3:45 PM

5:00 PM

  • EarthHouse: Critical Minerals, Mobility & Modern Power: See Details Here
    The Strategye Group, Alpha Sierra One

6:00 PM – 9:00 PM

6:00 PM

  • Pizza+Soda: *Invite Only*
    Schmoozd , The KINN

7:00 PM

VENICE BEACH

2:00 PM – 6:30 PM

5:00 PM

8:30 PM – 2:00 AM

VIRTUAL (LA)

2:30 PM – 4:00 PM

3:00 PM

  • Government of Alberta: ProcurementAsCode // Done in 60 Seconds: See Details Here
    Government of Alberta

4:00 PM

  • Stop Hitting Yourself 🥊: See Details Here
    Stop Hitting Yourself, HOWDY, Company Policy, Snowbird Global

WEST HOLLYWOOD

3:00 PM – 6:00 PM

6:00 PM

WESTSIDE

5:00 PM

5:30 PM – 8:30 PM


For updates or more event information, visit the official Tech Week calendar.

Enjoy LA Tech Week 2025!

Download the dot.LA App


RELATEDEDITOR'S PICKS
Trending