
Get in the KNOW
on LA Startups & Tech
X
From Stem Cells to Biosensors: 3 Trends To Watch at This Year’s First Look Startup Showcase
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
Some 15-odd years ago, the Alliance for SoCal Innovation put on a workshop for academics looking to wade into the world of commercialized technology.
Fast forward to 2022 and the Alliance is gearing up for the latest edition of its annual First Look SoCal Innovation Showcase, taking place Tuesday at the Skirball Cultural Center. This year’s lineup of 24 early-stage life sciences and tech startups—tapped from the Alliance’s network of universities and incubators—will have the chance to pitch their ventures and meet with potential investors, mentors and industry executives as they look for what, in most cases, will be their first round of commercial funding.
The life cycle of biotech and medtech companies often starts at the academic level, where universities like Caltech, USC and UCLA pump research dollars into PhD projects and incubate them for a few years until there’s proof of concept. Others are incubated at research institutions like the Lundquist Institute or City of Hope. From there, those projects that choose to become startups are spun out into standalone ventures and begin their hunt for venture capital money.
“This is often a perilous journey from lab to market,” Steve Gilison, the Alliance for SoCal Innovation’s chief operating officer, told dot.LA. “So we don't just think of this as an investment pitch, but as an opportunity to really make the right connections.”
It also gives the rest of us a peek into what kind of cutting-edge technology is most interesting to early-stage SoCal investors. Here’s what we can glean from this year’s cadre of startups at the First Look showcase.
Stem Cell Therapy Could Replace Current Invasive Treatments
Stem cell therapy continues to be one of the most prominent trends in disease treatment. Some of the largest biotech companies working on stem cell therapies are based in Los Angeles; the Food and Drug Administration recently approved Santa Monica-based Kite Pharma’s CAR-T cell treatment for some forms of cancer, which could reduce or even eliminate the need for extensive radiation or other treatments loaded with dangerous side effects.
A handful of biotech startups at the First Look showcase are utilizing stem cells to tackle diseases in a similar manner. Chimera Therapeutics, a startup out of City of Hope, uses “mixed chimerism”—where stem cells from a donor and the patient are mixed together in the patient’s tissue—to treat autoimmune disorders like multiple sclerosis. The goal is to use donor stem cells to help boost a weakened immune system and potentially halt the progression of a disorder.
Simurx, another showcase participant that’s a product of Children’s Hospital Los Angeles, is following local biotechs like Kite and Appia Bio in deploying CAR-T cell therapy—in Simurx’s case, to address solid tumors.
Despite how promising these cell therapies have been, the technology is still rather new, largely cost-prohibitive and comes with long wait times for patients. UC Irvine’s Cellecho aims to make the process of creating these therapies faster through precision engineering. Most existing tools on the market require great care to precisely engineer cells, which make them hard to scale and can lead to longer wait times to receive treatment. Cellecho’s tool—called the Acoustic-Electric Shear Orbiting Poration—is able to deliver genetic coding molecules into several cells at once. It can be automated and the disposable cartridges can be mass-produced, which should drive down costs.
Cultured Meat May Do Away with Unsustainable Meat Farming
Lab-grown meat promises to bring humane, environmentally-friendly disruption to a global meat market that is projected to be a $2.7 trillion industry by 2040, according to CB Insights. Some of the largest meat manufacturers in the U.S., such as Tyson Foods, have already invested in cultured meat that only requires a few animal cells to cultivate a protein. If embraced, these technologies could eventually do away with the need for factory farming, which accounts for 70% of the U.S.’s ammonia emissions.
Bluefin Foods, a UCLA spin-out, is entering the foray with lab-grown seafood cultivated from animal cells. The company says its technology, if borne out, could replace commercial fishing, which contributes to fish depopulation and ocean habitat degradation.
At this stage, lab-grown meat is still more expensive than its factory-farmed counterpart. But if startups like Bluefin are able to gain traction and scale, that may not be the case in the future.
The Biosensor Sector Could Pave the Way for Preventative Health Care
As the American health care industry struggles to provide a preventative model—one that would help patients avoid illnesses and ailments while lowering health care spending overall—a few nascent ventures are attempting to leverage technology to make out-of-reach tests and treatments easier to access.
UCLA’s ViBo Health is in the backyard of one of Apple’s preferred biosensor manufacturers: Pasadena-based Rockley Photonics, which makes sensors that track blood pressure, hydration and a slew of other biomarkers. Wearables like the Apple Watch and Google’s Fitbit are among the largest customers for biosensors that were once reserved for the doctor’s office.
ViBo’s trajectory, however, is slightly different. Rather than affixing its biosensors to the body, its scanners—which track cholesterol, glucose and cardiac biomarkers—will be in pharmacies, clinics, gyms and offices. Lowering the barrier to entry and allowing patients to more quickly and easily check their own biomarkers may unburden the diagnostics space, as routine tests can be cost- and time-prohibitive for labs that often have more pressing tests to run.
Zoetic Motion, a startup in the physical therapy space, is taking a different approach. Physical therapy attendance among patients after a stroke or injury is notoriously low, yet critical to ensuring a full recovery and preventing a recurrence. Through an interactive and gamified platform, Zoetic allows physical therapists to prescribe exercise routines that promise to improve patients’ engagement and help them build habits that keep them out of the hospital. One L.A.-based startup and First Look alum, Moving Analytics, raised $6 million in seed funding last year with a similar philosophy toward improving patient engagement at rehabilitation centers.
Besides Moving Analytics, several other startups that previously participated in the First Look showcase have also gone on to raise funds from investors. One notable success story is San Diego-based RNA therapeutics firm DTx Pharma, which has raised more than $100 million since it first appeared at the showcase in 2019.
This year’s crop of ambitious young companies will hope Tuesday’s event can be a platform that helps them replicate that kind of success.
- First Look Socal Innovation Showcase - dot.LA ›
- Meet 3 Early Stage Science Startups at First Look's Showcase - dot.LA ›
- First Look Features Life Science Startups from SoCal Schools - dot.LA ›
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
Subscribe to our newsletter to catch every headline.
At Electrify Expo 2022, Cars Aren't the Only EVs Sparking Interest
“If you get the chance, make sure to test drive a Toyota.”
I’m walking down a row of booths at Electrify Expo at the Long Beach Convention Center on a hot June day. I thank the red-shirted brand ambassador and scurry towards the nearest e-scooter.
Sorry, Toyota. I’m not here for the cars.
Electrify Expo—the biggest outdoor electric vehicle festival in the U.S.—took place this past weekend and e-scooters, e-bikes and other micro EVs took center stage.
At an event focused on electrification, more than half of the companies represented were in the micromobility space. And there’s a good reason for that.
According to industry leaders, electrification means significant room for growth in the market as American consumers emerge from the dark years of the pandemic and seek out more active and eco-friendly modes of transportation.
Only 6% of bikes sold in the U.S. are e-bikes, compared to a rate of 17% in Europe and 50% in the Netherlands, said Claudia Wasko, vice president and general manager of Bosch eBike Systems, at the event’s Industry Day.
“Last year, 2021, in Europe, almost 6 million e-bikes have been sold; just in Germany, 2 million e-bikes have been sold. And in the US, not even 1 million. But this shows us the huge potential we still have,” she said.
Industry speakers also praised European countries for their adoption of comprehensive micromobility infrastructure.
“If you drive around Los Angeles… you'd have a tough time being on an electric bike or an electric scooter or even one of our mopeds, that can hit speeds of 60 miles an hour,” said Joseph Constanty, director of global strategy at Niu. “You still feel out of place when a huge Ford Ranger F-150 comes riding up right next to you and you're dwarfed by it. It's an infrastructure problem.”
Companies are banking on a cultural shift as Americans get out of their cars and onto an e-bike, moped or e-scooter.
Jesse Lapin, chief operating officer of Magnum Bikes, suggested that it’s less of a shift and more of a return. Americans ride their bikes as children and then abandon them in the garage as soon as they turn 16. However, driving itself might be going out of style; millennials are driving less than their elders and Gen Z is in no rush to get in the driver’s seat (of a car). And who can blame them? Gas prices have hit record highs with no sign of relief on the horizon.
What are they gonna do, take the bus? JackRabbit Mobility is hoping they take a micro e-bike instead, with a 24 pound, 20 mile-per-hour device marketed to college students and other casual riders. But why stop with one? Lapin sees the future American garage filled with not one, but two e-bikes as the market diversifies.
“E-bikes truly are the best way to communicate and to connect people with other people, people with places, people with views. It's the best way to visit national parks; it's the best way to get out there and connect with yourself,” he said.
And there’s one other advantage to micromobility: It’s hella fun. And with a looming recession and two years and counting into a pandemic, American adults with disposable income just want eco-friendly toys that go zoom. Or at least that’s what the industry is banking on.
It’s true: When I’m flying around the test track on an e-bike and I hit the throttle, getting that coveted 28-miles-per-hour, I feel like a kid again.
Provide a mode of transportation that you can charge from the comfort of your one-bedroom apartment, one that’s fun, good for the environment and lets you fly past stopped rush hour traffic on Venice Boulevard?
Cars could never.
- Xos Trucks Launches Mobile Charging Stations for Fleets - dot.LA ›
- Electrify America Invests $200M in Southern California - dot.LA ›
- Users With Disabilities Can Rent Bird Scooters in Long Beach - dot.LA ›
Starting today, Glendale’s most meme-able outdoor mall, The Americana at Brand, will be home to the Amazon Style store—the ecommerce giant’s first foray into brick-and-mortar apparel retail. We got an early sneak peak inside the new digs (located on the corner with Sprinkles Cupcakes, next to H&M and the Apple store) and were able to try out some of its tech-enabled features, which—as ever with Amazon—seek to make the act of shopping as easy as possible.
1. It’s Bigger Than It Looks—Even From the Inside
The floor is massive—laying out original products from Amazon’s own apparel lines alongside name brands like Theory, Adidas and Calvin Klein, as well as several other lines that have up until now only existed online. But the actual store is much larger than the two floors that most customers will only ever see.
Amazon Style is just the front—the homepage, if you will—behind which a large warehouse facility keeps a gigantic surplus of inventory. A floor-to-ceiling glass window on the main floor gives shoppers just a peak behind the scenes, as employees help load industrial-sized elevators with racks of goods to send upstairs to the dressing rooms.
2. Online Shopping IRL
When perusing the store’s bouquet of cottagecore maxi dresses, Kendall & Kylie blazers and, yes, a whole section dedicated to Y2K apparel, one doesn’t just pick an item off the rack and take it with you while you shop. Instead, each rack has a barcode that you can scan via the Amazon Shopping app, which has your sizes pre-loaded from previous purchases. (You can opt for a different size if you choose.) That cues an AI-enabled algorithm to start searching through the store’s warehoused catalog and zip the desired item over to the second floor, where the dressing room provides its own glimpse into the future of shopping.
The store also boasts a version of The Drop, an Amazon staple that allows online customers to shop entire influencer-curated collections for a 30-hour flash window.
3. Changing Stations of the Future—Today
Your phone also acts as your keycard to get into your personal dressing room. To prevent waiting, you are put in a virtual cue the moment you scan your first item; should the Amazon app prompt that your room is ready while you’re still shopping, a tap of your screen allows you to hold your spot in the queue while freeing up the room for someone else. (And if your phone dies while you’re waiting, Amazon says a Style employee on the floor will be happy to help you keep your place in line, or hook you up with a charge.)
Amazon Style’s dressing rooms offer a tech-enabled twist to trying on clothes.Image by Joshua Letona
The changing room is like its own parlor trick. Designed to look like a walk-in closet, one wall has a full-length mirror and a giant touchscreen while another has all the clothes you scanned in your style and size preference. Expect to see a few surprises in there, as Amazon’s algorithm picks out other stuff you might want to try on based on your picks. It would be spooky if it wasn’t so convenient—an IRL mashup of the online retailer’s “Recommended Based on Your Purchases” and “Frequently Bought Together” features.
If an item doesn’t fit quite right or you want to see how a skirt looks in blue instead of black, just tap the touchscreen to request a variant. Or an entirely new outfit, as the screen makes available everything in the facility. Then just bring it down to checkout—perhaps the wildest part of this ride.
4. Palming the Bucks
Checking out of Amazon Style’s flagship store is what really blew my mind—although apparently it’s because I haven’t been to one of the Amazon Go, Amazon Fresh or Whole Foods locations where cashless checkouts have been an option in select stores since 2020.
I assumed you could just walk out the door with your purchase, because I watch "Saturday Night Live" sketches for news. While the Go payment option isn't available at Amazon Style, there are several checkout options to keep the experience as frictionless and non-cumbersome as possible.
One way is to take the clothes you want out of the dressing room and go directly to Amazon’s palm-enabled checkout kiosks. That’s right: Register on the spot for an Amazon One account, and you need merely to wave your hand over a little black device that reads your palm and charges your on-file payment method. It’s super convenient for everyone except $10 boardwalk psychics, who just may be put out of business by such technology.
For the more traditional set, you still have the option of paying via credit card or cash.
Shoppers can check out of Amazon Style with the wave of a palm.
Image by Joshua Letona
5. Supply & Demand & Return
Amazon Style’s brick-and-mortar location opens up a variety of new ways to shop, return and exchange clothing. For instance, you can order a load of clothes online and pick them up in the store; anything you don’t want can be returned in the store without you ever having to print a shipping label.
See something you like but don’t have time to try it on? Just scan the barcode, pick it up at the front of the store and pay on your way out without ever going into a dressing room.
The Amazon Shopping app also boasts a Deals feature, which automatically sorts for the best price on items to help customers either save money (or believe they are).
While Glendale is home to the only Style store so far, Amazon isn’t ruling out more locations. With fewer retailers able to afford rents on America’s main strips and shopping malls, Amazon’s resources—and its unique position at the intersection of tech and retail—make it easy to envision more Style stores on the horizon.
Drew Grant is dot.LA's Senior Editor. She's a media veteran with over 15-plus years covering entertainment and local journalism. During her tenure at The New York Observer, she founded one of their most popular verticals, tvDownload, and transitioned from generalist to Senior Editor of Entertainment and Culture, overseeing a freelance contributor network and ushering in the paper's redesign. More recently, she was Senior Editor of Special Projects at Collider, a writer for RottenTomatoes streaming series on Peacock and a consulting editor at RealClearLife, Ranker and GritDaily. You can find her across all social media platforms as @Videodrew and send tips to drew@dot.la.