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From Stem Cells to Biosensors: 3 Trends To Watch at This Year’s First Look Startup Showcase
Keerthi Vedantam
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
Some 15-odd years ago, the Alliance for SoCal Innovation put on a workshop for academics looking to wade into the world of commercialized technology.
Fast forward to 2022 and the Alliance is gearing up for the latest edition of its annual First Look SoCal Innovation Showcase, taking place Tuesday at the Skirball Cultural Center. This year’s lineup of 24 early-stage life sciences and tech startups—tapped from the Alliance’s network of universities and incubators—will have the chance to pitch their ventures and meet with potential investors, mentors and industry executives as they look for what, in most cases, will be their first round of commercial funding.
The life cycle of biotech and medtech companies often starts at the academic level, where universities like Caltech, USC and UCLA pump research dollars into PhD projects and incubate them for a few years until there’s proof of concept. Others are incubated at research institutions like the Lundquist Institute or City of Hope. From there, those projects that choose to become startups are spun out into standalone ventures and begin their hunt for venture capital money.
“This is often a perilous journey from lab to market,” Steve Gilison, the Alliance for SoCal Innovation’s chief operating officer, told dot.LA. “So we don't just think of this as an investment pitch, but as an opportunity to really make the right connections.”
It also gives the rest of us a peek into what kind of cutting-edge technology is most interesting to early-stage SoCal investors. Here’s what we can glean from this year’s cadre of startups at the First Look showcase.
Stem Cell Therapy Could Replace Current Invasive Treatments
Stem cell therapy continues to be one of the most prominent trends in disease treatment. Some of the largest biotech companies working on stem cell therapies are based in Los Angeles; the Food and Drug Administration recently approved Santa Monica-based Kite Pharma’s CAR-T cell treatment for some forms of cancer, which could reduce or even eliminate the need for extensive radiation or other treatments loaded with dangerous side effects.
A handful of biotech startups at the First Look showcase are utilizing stem cells to tackle diseases in a similar manner. Chimera Therapeutics, a startup out of City of Hope, uses “mixed chimerism”—where stem cells from a donor and the patient are mixed together in the patient’s tissue—to treat autoimmune disorders like multiple sclerosis. The goal is to use donor stem cells to help boost a weakened immune system and potentially halt the progression of a disorder.
Simurx, another showcase participant that’s a product of Children’s Hospital Los Angeles, is following local biotechs like Kite and Appia Bio in deploying CAR-T cell therapy—in Simurx’s case, to address solid tumors.
Despite how promising these cell therapies have been, the technology is still rather new, largely cost-prohibitive and comes with long wait times for patients. UC Irvine’s Cellecho aims to make the process of creating these therapies faster through precision engineering. Most existing tools on the market require great care to precisely engineer cells, which make them hard to scale and can lead to longer wait times to receive treatment. Cellecho’s tool—called the Acoustic-Electric Shear Orbiting Poration—is able to deliver genetic coding molecules into several cells at once. It can be automated and the disposable cartridges can be mass-produced, which should drive down costs.
Cultured Meat May Do Away with Unsustainable Meat Farming
Lab-grown meat promises to bring humane, environmentally-friendly disruption to a global meat market that is projected to be a $2.7 trillion industry by 2040, according to CB Insights. Some of the largest meat manufacturers in the U.S., such as Tyson Foods, have already invested in cultured meat that only requires a few animal cells to cultivate a protein. If embraced, these technologies could eventually do away with the need for factory farming, which accounts for 70% of the U.S.’s ammonia emissions.
Bluefin Foods, a UCLA spin-out, is entering the foray with lab-grown seafood cultivated from animal cells. The company says its technology, if borne out, could replace commercial fishing, which contributes to fish depopulation and ocean habitat degradation.
At this stage, lab-grown meat is still more expensive than its factory-farmed counterpart. But if startups like Bluefin are able to gain traction and scale, that may not be the case in the future.
The Biosensor Sector Could Pave the Way for Preventative Health Care
As the American health care industry struggles to provide a preventative model—one that would help patients avoid illnesses and ailments while lowering health care spending overall—a few nascent ventures are attempting to leverage technology to make out-of-reach tests and treatments easier to access.
UCLA’s ViBo Health is in the backyard of one of Apple’s preferred biosensor manufacturers: Pasadena-based Rockley Photonics, which makes sensors that track blood pressure, hydration and a slew of other biomarkers. Wearables like the Apple Watch and Google’s Fitbit are among the largest customers for biosensors that were once reserved for the doctor’s office.
ViBo’s trajectory, however, is slightly different. Rather than affixing its biosensors to the body, its scanners—which track cholesterol, glucose and cardiac biomarkers—will be in pharmacies, clinics, gyms and offices. Lowering the barrier to entry and allowing patients to more quickly and easily check their own biomarkers may unburden the diagnostics space, as routine tests can be cost- and time-prohibitive for labs that often have more pressing tests to run.
Zoetic Motion, a startup in the physical therapy space, is taking a different approach. Physical therapy attendance among patients after a stroke or injury is notoriously low, yet critical to ensuring a full recovery and preventing a recurrence. Through an interactive and gamified platform, Zoetic allows physical therapists to prescribe exercise routines that promise to improve patients’ engagement and help them build habits that keep them out of the hospital. One L.A.-based startup and First Look alum, Moving Analytics, raised $6 million in seed funding last year with a similar philosophy toward improving patient engagement at rehabilitation centers.
Besides Moving Analytics, several other startups that previously participated in the First Look showcase have also gone on to raise funds from investors. One notable success story is San Diego-based RNA therapeutics firm DTx Pharma, which has raised more than $100 million since it first appeared at the showcase in 2019.
This year’s crop of ambitious young companies will hope Tuesday’s event can be a platform that helps them replicate that kind of success.
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Keerthi Vedantam
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
https://twitter.com/KeerthiVedantam
keerthi@dot.la
🤫 The Secret to Staying Fit at Your Desk: 6 Essential Under-Desk Exercise Machines
06:26 PM | July 24, 2024
Health experts are sounding the alarm: our sedentary jobs are slowly killing us, yet we can't abandon our desks if we want to keep the lights on. It feels like we're caught between a rock and a hard place. Enter under-desk exercise machines – the overlooked heroes (albeit kind of goofy looking) of the modern workspace. These devices let tech professionals stay active, enhance their health, and increase their productivity, all without stepping away from their screens. Here are 6 fantastic options that will enhance the way you work and workout simultaneously.
DeskCycle Under Desk Bike Pedal Exerciser
This bike has nearly ten thousand five-star reviews on amazon. It works with nearly any desk/chair setup. It is quiet, sturdy and allows up to 40 pounds of resistance. If you are looking for an under-desk bike this is a fantastic option.
Type: Under-Desk Bike
Price: $180 - $200Sunny Health & Fitness Dual Function Under Desk Pedal Exerciser
This under-desk bike is extremely quiet due to the magnetic resistance making it an ideal option if you work in a shared space. It doesn’t slip, has eight levels of resistance, and the option to work legs and arms. It’s about half the price of the DeskCycle bike making it a solid mid-range option for those looking to increase their daily activity.
Type: Under-Desk Bike
Price: $100 - $110Sunny Health & Fitness Sitting Under Desk Elliptical
This under-desk elliptical comes in multiple colors if you really want to underscore that you are a quirky individual, in case an under-desk elliptical isn’t enough. This model is a bit heavy (very sturdy), has eight different resistance levels, and has more than nine thousand 5-star reviews.
Type: Under-Desk Elliptical
Price: $120 - $230
DeskCycle Ellipse Leg Exerciser
This under-desk elliptical is another great option. It is a bit pricey but it’s quiet, well-made and has eight resistance levels. It also syncs with your apple watch or fitbit which is a very large perk for those office-wide “step” challenges. Get ready to win.
Type: Under-Desk Elliptical
Price: $220 - $230Daeyegim Quiet LED Remote Treadmill
If you have a standing desk and are looking to walk and work this is a fantastic option. This walking-only treadmill allows you to walk between 0.5 to 5 mph (or jog unless you have the stride length of an NBA forward). It is very quiet, which is perfect if you want to use it near others or during a meeting. You can’t change the incline or fold it in half but it is great for simply getting in some extra steps during the work day.
Type: Under-Desk Treadmill
Price: $220 - $230Sunny Health & Fitness Foldable Manual Treadmill
This under-desk treadmill isn’t the most premium model but it is affordable and has an impressive array of features. It is a manual treadmill meaning it doesn’t need to be plugged in; it is foldable and offers an incline up to 13%. I personally can’t imagine working and walking up a 13% incline but if that sounds like your cup of tea, then I truly respect the hustle.
Type: Under-Desk Treadmill
Price: $150 - $200Read moreShow less
LA’s Upgrade in Travel and NBA Viewing
08:41 AM | July 26, 2024
Image Source: Los Angeles World Airports
🔦 Spotlight
Exciting developments are underway for Los Angeles as the city prepares for major upgrades in both travel and entertainment. The Los Angeles Board of Airport Commissioners has approved an additional $400 million for the Automated People Mover (APM) at LAX, increasing its total budget to $3.34 billion. This boost ensures the elevated train’s completion by December 8, 2025, with service starting in January 2026. For Angelenos, this means a significant improvement in travel convenience. The APM will streamline connections between parking, rental car facilities, and the new Metro transit station, drastically cutting traffic congestion around the airport. Imagine a future without the dreaded 30-minute traffic delays at LAX! The APM will operate 24/7, reducing airport traffic by 42 million vehicle miles annually and carrying 30 million passengers each year, while also creating thousands of local jobs and supporting small businesses.
Meanwhile, the NBA is also making waves with its new broadcasting deals. The league has signed multi-year agreements with ESPN, NBC, and Amazon Prime Video, marking a notable shift in media partnerships. ESPN will maintain its long-standing role, NBC returns as a network broadcaster after years away, and Amazon Prime Video will provide NBA games through its streaming platform. Starting with the 2025-2026 season, these deals will enhance the league's reach and revenue, aligning with the NBA's goal to expand its audience and adapt to evolving viewing habits. Whether you're catching the action on TV or streaming online, these changes promise to elevate the fan experience and bring more basketball excitement to Los Angeles.
🤝 Venture Deals
LA Companies
- Pearl, a startup that makes AI-powered software that assists dentists in identifying cavities, gum disease, and other dental conditions, raised a $58M Series B funding led by Left Lane Capital with Smash Capital, and others also participating. - learn more
LA Venture Funds
- Fulcrum Venture Group participated in a prior $3.5M Pre-Seed Round for Code Metal, a developer tools startup. - learn more
- B Capital co-led a $12.5M Seed Round for Star Catcher, a startup that aims to develop a space-based grid that captures solar energy in space and distributes it to satellites and other space assets. - learn more
- Mantis VC and Amplify participated in a $140M Series C for Chainguard, an open source security startup. - learn more
- Prominent LA venture capitalist, Carter Reum and wife, Paris Hilton, participated in a $14M Seed/Series A for W, the men’s personal care brand from Jake Paul. - learn more
LA Exits
- Warner Bros. Games acquired Player First Games, developer of the recently launched MultiVersus free-to-play platform fighter videogame. - learn more
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