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From Stem Cells to Biosensors: 3 Trends To Watch at This Year’s First Look Startup Showcase
Keerthi Vedantam
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
Some 15-odd years ago, the Alliance for SoCal Innovation put on a workshop for academics looking to wade into the world of commercialized technology.
Fast forward to 2022 and the Alliance is gearing up for the latest edition of its annual First Look SoCal Innovation Showcase, taking place Tuesday at the Skirball Cultural Center. This year’s lineup of 24 early-stage life sciences and tech startups—tapped from the Alliance’s network of universities and incubators—will have the chance to pitch their ventures and meet with potential investors, mentors and industry executives as they look for what, in most cases, will be their first round of commercial funding.
The life cycle of biotech and medtech companies often starts at the academic level, where universities like Caltech, USC and UCLA pump research dollars into PhD projects and incubate them for a few years until there’s proof of concept. Others are incubated at research institutions like the Lundquist Institute or City of Hope. From there, those projects that choose to become startups are spun out into standalone ventures and begin their hunt for venture capital money.
“This is often a perilous journey from lab to market,” Steve Gilison, the Alliance for SoCal Innovation’s chief operating officer, told dot.LA. “So we don't just think of this as an investment pitch, but as an opportunity to really make the right connections.”
It also gives the rest of us a peek into what kind of cutting-edge technology is most interesting to early-stage SoCal investors. Here’s what we can glean from this year’s cadre of startups at the First Look showcase.
Stem Cell Therapy Could Replace Current Invasive Treatments
Stem cell therapy continues to be one of the most prominent trends in disease treatment. Some of the largest biotech companies working on stem cell therapies are based in Los Angeles; the Food and Drug Administration recently approved Santa Monica-based Kite Pharma’s CAR-T cell treatment for some forms of cancer, which could reduce or even eliminate the need for extensive radiation or other treatments loaded with dangerous side effects.
A handful of biotech startups at the First Look showcase are utilizing stem cells to tackle diseases in a similar manner. Chimera Therapeutics, a startup out of City of Hope, uses “mixed chimerism”—where stem cells from a donor and the patient are mixed together in the patient’s tissue—to treat autoimmune disorders like multiple sclerosis. The goal is to use donor stem cells to help boost a weakened immune system and potentially halt the progression of a disorder.
Simurx, another showcase participant that’s a product of Children’s Hospital Los Angeles, is following local biotechs like Kite and Appia Bio in deploying CAR-T cell therapy—in Simurx’s case, to address solid tumors.
Despite how promising these cell therapies have been, the technology is still rather new, largely cost-prohibitive and comes with long wait times for patients. UC Irvine’s Cellecho aims to make the process of creating these therapies faster through precision engineering. Most existing tools on the market require great care to precisely engineer cells, which make them hard to scale and can lead to longer wait times to receive treatment. Cellecho’s tool—called the Acoustic-Electric Shear Orbiting Poration—is able to deliver genetic coding molecules into several cells at once. It can be automated and the disposable cartridges can be mass-produced, which should drive down costs.
Cultured Meat May Do Away with Unsustainable Meat Farming
Lab-grown meat promises to bring humane, environmentally-friendly disruption to a global meat market that is projected to be a $2.7 trillion industry by 2040, according to CB Insights. Some of the largest meat manufacturers in the U.S., such as Tyson Foods, have already invested in cultured meat that only requires a few animal cells to cultivate a protein. If embraced, these technologies could eventually do away with the need for factory farming, which accounts for 70% of the U.S.’s ammonia emissions.
Bluefin Foods, a UCLA spin-out, is entering the foray with lab-grown seafood cultivated from animal cells. The company says its technology, if borne out, could replace commercial fishing, which contributes to fish depopulation and ocean habitat degradation.
At this stage, lab-grown meat is still more expensive than its factory-farmed counterpart. But if startups like Bluefin are able to gain traction and scale, that may not be the case in the future.
The Biosensor Sector Could Pave the Way for Preventative Health Care
As the American health care industry struggles to provide a preventative model—one that would help patients avoid illnesses and ailments while lowering health care spending overall—a few nascent ventures are attempting to leverage technology to make out-of-reach tests and treatments easier to access.
UCLA’s ViBo Health is in the backyard of one of Apple’s preferred biosensor manufacturers: Pasadena-based Rockley Photonics, which makes sensors that track blood pressure, hydration and a slew of other biomarkers. Wearables like the Apple Watch and Google’s Fitbit are among the largest customers for biosensors that were once reserved for the doctor’s office.
ViBo’s trajectory, however, is slightly different. Rather than affixing its biosensors to the body, its scanners—which track cholesterol, glucose and cardiac biomarkers—will be in pharmacies, clinics, gyms and offices. Lowering the barrier to entry and allowing patients to more quickly and easily check their own biomarkers may unburden the diagnostics space, as routine tests can be cost- and time-prohibitive for labs that often have more pressing tests to run.
Zoetic Motion, a startup in the physical therapy space, is taking a different approach. Physical therapy attendance among patients after a stroke or injury is notoriously low, yet critical to ensuring a full recovery and preventing a recurrence. Through an interactive and gamified platform, Zoetic allows physical therapists to prescribe exercise routines that promise to improve patients’ engagement and help them build habits that keep them out of the hospital. One L.A.-based startup and First Look alum, Moving Analytics, raised $6 million in seed funding last year with a similar philosophy toward improving patient engagement at rehabilitation centers.
Besides Moving Analytics, several other startups that previously participated in the First Look showcase have also gone on to raise funds from investors. One notable success story is San Diego-based RNA therapeutics firm DTx Pharma, which has raised more than $100 million since it first appeared at the showcase in 2019.
This year’s crop of ambitious young companies will hope Tuesday’s event can be a platform that helps them replicate that kind of success.
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Keerthi Vedantam
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
https://twitter.com/KeerthiVedantam
keerthi@dot.la
AirMap Will Help The FAA Design Its New Drone Tracking System
04:43 PM | May 06, 2020
Santa Monica-based drone operations company AirMap is among eight companies selected to help the Federal Aviation Administration establish technical requirements for Remote ID, a protocol that drones will be required to follow for broadcasting identification and location data while in flight.
The other companies include Airbus, Amazon, T-Mobile, Intel, OneSky, Skyward and Alphabet's drone subsidiary, Wing.
"The FAA will be able to advance the safe integration of drones into our nation's airspace from these technology companies' knowledge and expertise on remote identification," Transportation Secretary Elaine Chao said today in a news release.
Today's announcement comes months after the FAA put out a set of draft regulations and a request for information relating to Remote ID.
Remote ID would require drone manufacturers to make their products capable of sending out ID codes and location data during operation in national airspace. The rules would apply to all drones heavier than 8.8 ounces, and manufacturers would have to comply two years after the regulations take effect. Drone operators would have three years to phase out non-complying devices.
Drones without the Remote ID system could be flown only within special FAA-designated zones — usually the same sorts of places where hobbyists fly model airplanes.
Remote ID system proposed for drones in U.S. airspacewww.youtube.com
The eight companies named today will advise the FAA on the technical standards and radio frequencies that would support the Remote ID system. Those specifications will be announced when the FAA publishes its final rule on Remote ID. Then the FAA would begin accepting applications for entities to become Remote ID suppliers.
Assuming the process develops as the FAA envisions, Remote ID would become a fact of life for drone operation — and for enforcement of the rules governing drone operation. Nearly 1.5 million drones and 160,000 remote pilots are now registered with the FAA, and analysts say Remote ID could turn into a market generating $1.5 billion a year by 2029.
Seattle-based Amazon and Wing are already well-known for their work on drones designed for package delivery. Airbus has its own delivery-drone program known as Skyways. Intel, meanwhile, has been building drones optimized for remote monitoring. Several FAA-approved pilot projects are testing Intel's drones as well as Intel's Bluetooth-enabled identification system, known as Open Drone ID.
AirMap, OneSky (a business unit of Analytical Graphics Inc.) and Skyward (a Verizon subsidiary) are working on traffic management systems that are optimized to keep track of drone operations.
T-Mobile has been providing the connectivity for at least three pilot projects involving drones, and is looking to expand its involvement in the drone industry with the rise of 5G networks.
Not everyone is happy with the FAA's proposed plan for Remote ID: DJI, one of the world's largest drone manufacturers, sounded off about its objections in a January blog posting.
"DJI wants governments to require Remote ID for drones, but the FAA has proposed a complex, expensive and intrusive system that would make it harder to use drones in America, and that jeopardizes the success of the Remote ID initiative," said Brendan Schulman, DJI's vice president of policy and legal affairs. "Instead, we support a simpler, easier, and free version of Remote ID that doesn't need a cellular connection or a service subscription."
Will the FAA's new technology partners come up with a different plan, or stick with the system as proposed? Stay tuned.
This story first appeared on GeekWire.
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Alan Boyle, GeekWire
GeekWire contributing editor Alan Boyle is an award-winning science writer and veteran space reporter. Formerly of NBCNews.com, he is the author of "The Case for Pluto: How a Little Planet Made a Big Difference." Follow him via CosmicLog.com, on Twitter @b0yle, and on Facebook and MeWe.
Tinder, Starlink, and Apple’s New Studio: This Week in LA
10:27 AM | July 04, 2025
🔦 Spotlight
Happy Independence Day, Los Angeles! 🇺🇸
While you're celebrating freedom, here are some electrifying updates lighting up LA’s tech, satellite, and music scenes:
🔥 Tinder mandates Face Recognition in California
Image Source: Tinder
Tinder is now requiring all new users in California to complete a biometric face check, a brief video selfie processed via FaceTec, to verify profiles are genuine. The video is deleted post-verification, though an encrypted face map remains while the account is active. This West Hollywood based move could redefine trust, safety, and privacy in mainstream consumer apps.
🌐 Starlink clears hurdle to launch in India
Elon Musk’s SpaceX backed Starlink has cleared most regulatory and licensing hurdles with India’s Department of Telecommunications, marking a key step toward launching satellite broadband in one of the world’s fastest growing markets. Final approvals from the national space regulator are pending, and services, expected to deliver high speed connectivity to underserved regions, could launch in the coming months. This is a major milestone for Starlink’s global expansion.
🎧 Apple Music opens Culver City creative hub
Image Source: Apple
Apple Music is celebrating its anniversary by launching a brand new 15,000 square foot, three story studio in Culver City. The facility, featuring a 4,000 square foot soundstage, spatial audio suites, podcast booths, and more, is designed by Eric Owen Moss and slated to open mid August. It solidifies LA’s reputation as a creative powerhouse and reaffirms Apple’s commitment to investing in and nurturing our city's cultural ecosystem.
From dating apps to deep space to sound stages, LA isn’t just watching the future unfold, we’re building it.
Here’s to independence, imagination, and everything this city dares to launch next. Happy Fourth, Los Angeles.
🤝 Venture Deals
LA Companies
- Castelion has raised a $350M Series B round led by Lightspeed Venture Partners alongside Altimeter Capital to scale its hypersonic missile production capabilities. The El Segundo-based defense startup plans to use the funds to expand manufacturing, accelerate testing through its SpaceX-inspired rapid development model, and position itself as a cost-effective supplier of hypersonic weapons to the U.S. military and its allies. - learn more
- Earth Sama, a Calabasas, California–based climate-tech platform that helps rural farming and Indigenous communities generate and manage carbon credits, secured investment from Omtse Ventures. The funding will support the rollout of Earth Sama’s blockchain-powered field app, climate-creator platform, and smart-contract tools to scale community-led carbon credit projects globally under the Paris Agreement’s Article 6.4 framework. - learn more
LA Venture Funds
- Plassa Capital participated in Metafide’s $3.275M funding round. Miami based Metafide, the creator of SURGE, a gamified trading platform that combines AI neural networks and human insight, will use the funds to scale and launch SURGE into the market. - learn more
- BOLD Capital Partners participated as a founding investor in Syntis Bio’s $33M Series A round, with an additional $5M in NIH grants. The Boston-based biotech is developing oral therapies for obesity and rare diseases, and the funding will help advance its SYNT platform, moving its lead obesity treatment, SYNT-101, into Phase 1 trials and supporting development of SYNT-202 for homocystinuria. - learn more
- BAM Ventures participated in Cred’s $15M seed round for its predictive intelligence startup. San Francisco based Cred uses AI to unify company data with real time market signals and deliver actionable insights for sales and operations. The funding, led by defy.vc, will be used to scale Cred’s platform, expand its customer base, and grow team and product capabilities. - learn more
- BOLD Capital Partners participated in Gallant’s $18M Series B round to advance its ready-to-use stem cell therapies for pets. The funding, led by Digitalis Ventures with additional support from NovaQuest Capital, will help Gallant bring its off-the-shelf regenerative treatments to market. - learn more
- Rebel Fund joined the seed round for Rocketable, contributing to the $6.5M raised to build a portfolio of fully automated SaaS companies. San Francisco-based Rocketable, backed by True Ventures and others, uses AI agents to operate acquired software products, and Rebel’s support will help scale both the platform and acquisitions. - learn more
LA Exits
- Leasepath, a cloud-first provider of equipment lease and loan management software, has been acquired by Solifi to enhance its mid-market offerings. The deal allows Solifi to expand Leasepath’s Microsoft Dynamics-based platform into new global markets while keeping Leasepath’s team and leadership in place. - learn more
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