ImmPACT Bio Raises $111 Million to Advance Promising Cancer Therapies

Keerthi Vedantam

Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.

ImmPACT Bio
Image courtesy of ImmPACT Bio

When Sumant Ramachandra first stumbled upon oncology startup ImmPACT Bio, the Harvard Medical physician-turned-pharmaceutical executive was preparing to move his family to Los Angeles from Illinois, where he had worked as Baxter International’s president of pharmaceuticals. Though he had spent recent years running research and development arms and managing regulatory processes, Ramachandra’s background in immunology and oncology drew him to the company.

“It was a bit like coming home—and very humbling to see how far the field has gone from the time I was a researcher in the late 1990s to where it is today,” Ramachandra said.


Ramachandra joined Camarillo-based ImmPACT Bio as the company’s new president and CEO in November, at a time when the startup was drawing the attention of venture capital firms after showing promising early results in treating non-Hodgkin’s lymphoma. That progress has now paid off: On Thursday, the company announced a $111 million Series B funding round led by venBio—a prolific investor in cell therapy and cancer treatments—as well as Foresite Capital and Decheng Capital. The new funding follows an $18 million Series A round that ImmPACT raised in 2020.

Sumant Ramachandra

ImmPACT Bio President and CEO Sumant Ramachandra.

Courtesy of ImmPACT Bio

The five-year-old firm is one of several creating promising cancer therapies known as CAR-T cell therapies, which use genetically-engineered T cells to identify and eliminate cancer cells. Large players in the biopharma world, including Santa Monica-based Kite Pharma and Thousand Oaks-based Amgen, are looking to treat a variety of diseases using CAR-T cell therapy.

But there are still problems with the technology. Current CAR-T cell treatments of non-Hodgkin’s lymphoma struggle with antigen escape—which is when the immune cells on the tumor deplete, allowing it to grow or come back. A weakened immune system has trouble attacking cancers because they sometimes secrete molecules that suppress the immune system, and a number of patients end up relapsing after treatment.

The company’s CAR-T cell therapies aim to address those issues and more, by engineering a patient’s own cells to be able to bolster the immune system. A phase 1 clinical trial at UCLA is showing promising results: Seven out of eight patients, all of whom had undergone several other cancer treatments before being dosed, achieved complete remission.

“You're talking about a potential best in class,” Ramachandra said. “And a potential best in class therapy means maybe this can be taken to the centers that are currently not doing CAR-T cell therapy… Maybe there's a potential to make this more broadly applicable and available to patients.”

Though promising, technology will need to evolve for this process to scale. Genetically engineering a patient’s own cells and dosing them can take more than a week, which can be too long a wait for late-stage cancer patients who have already tried several other treatments. Other companies are working to create off-the-shelf CAR-T therapies using other peoples’ cells, which would allow cancer patients to get treated faster. But those therapies can also pose a danger to a cancer patient’s weakened immune system.

ImmPACT Bio will use the funding to move its headquarters to West Hills, in the western San Fernando Valley, and grow its team in manufacturing and research. The company also announced Sheila Gujrathi, a longtime biotech veteran who held leadership positions at Bristol Myers Squibb and Genentech, as the new chair of its board of directors.

“It's a really exciting period to be experiencing here,” Ramachandra said.

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Cadence

Another Round of Layoffs Points to the Growing Tension Within the Tech Industry

Lon Harris
Lon Harris is a contributor to dot.LA. His work has also appeared on ScreenJunkies, RottenTomatoes and Inside Streaming.
Another Round of Layoffs Points to the Growing Tension Within the Tech Industry
Drew Grant Midjourney

According to a new report from Bloomberg, Facebook and Instagram owner Meta are planning a fresh, significant round of layoffs that could happen as soon as this week. Thousands of employees are expected to lose their jobs, and that’s after the company cut 11,000 workers – 13% of its total workforce – in November of last year.

The November cuts were part of an ongoing project Meta leadership has dubbed “flattening,” an attempt to reorganize the entire company from the top-down to make it more “nimble.” CEO Mark Zuckerberg has dubbed 2023 Meta’s “Year of Efficiency,” in an attempt to familiarize employees with his thinking and prepare them for the changes to come. Broadly, the thinking goes that, while multiple layers of management and supervision make organizations more predictable and reliable, the bureaucracies ultimately stifle innovation and individual employee development. As well, they make the organizations slower to react to change, because so many different individuals on so many layers have to re-evaluate and alter their workflows.

The latest round of cuts is not directly connected to the flattening plan, according to internal sources who spoke with Bloomberg, but will be made out of necessity, due to a downturn in ad revenue and a shift in focus toward the Metaverse. They’re the latest indication of Meta’s increasing desperation for new revenue streams. (Fortune reports that the layoffs ALONE likely cost Meta around $88,000 per employee.)

Regardless of the specific motivations behind the layoffs, and beyond their immediate costs, dropping so much staff in so little time is bound to have some ongoing consequences and ripple effects. Even before Bloomberg’s report about new layoffs, Meta’s flattening project and “Year of Efficiency” announcement was already being blamed for a downtown in productivity at the company. In February, the Financial Times reported that Meta managers lacked clarity around their team budgets, headcounts, and other important information, making them functionally unable to plan for their workloads and ongoing projects. Some staffers told FT that “zero work” was being done amid all the uncertainty, adding that the Year of Efficiency began with “a bunch of people getting paid to do nothing.”

Elon Musk’s Twitter has also entered the “Find Out” phase after F*cking Around with layoffs over the past several months. On two separate recent occasions, minor code changes to the microblogging platform and social network caused widespread problems and outages. Most recently, on Monday, what Musk described as a “small API change” behind the scenes interrupted Twitter users’ ability to post both links and images. Musk blamed an “extremely brittle… code stack” which will ultimately require a “complete rewrite” to fully repair, but it’s worth pointing out that Twitter rarely had these kinds of widespread major outages before letting go of a considerable chunk of its engineering squad.

Beyond the organizational and practical impacts of losing so many people so quickly, there are also bound to be long-term implications for recruitment and morale. On Monday, the same day that links and images broke platform-wide, Musk was confronted publicly on the app by an Icelandic employee (or former employee, depending on who you believe) named Haraldur Thorleifsson, or Halli for short.

Thorleifsson – who has muscular dystrophy and uses a wheelchair for mobility – founded a creative agency named Ueno in 2014, which had partnered with Twitter on a number of design and product experiences over the years. In 2021, well prior to Musk’s direct involvement with the company, Twitter acquired Ueno and brought in Thorleifsson as an employee. He explained in a series of tweets to Musk on Monday that he’d lost remote access to Twitter’s system, and was unable to confirm with HR whether or not this was because he’d been terminated from the company. Musk responded aggressively, with a string of questions and challenges implying that Thorleifsson’s work was not providing value, and even referring to his disability as an “excuse.” He added “you can’t be fired if you weren’t working in the first place.” Thorleifsson’s stinging response, sent on Tuesday morning, now has nearly 30,000 retweets and over 200,000 likes, at the time of this newsletter’s publication.

PR-wise, it’s probably a bad look for Musk, and he may even be potentially running afoul of some Californian and international labor laws, if the thread’s many commenter-spectators are to be believed. But the situation also points to a larger tension within the technology industry, between managers who rely on what they view as essentially an infinite supply of fresh young talent eager to work for big brands and hot startups, and a pandemic-hardened workforce that has come to expect more equitable treatment and compensation.

University College of London professor Anthony Klotz – who originally coined the term “The Great Resignation” in May 2021 to refer to all the people who quit their job during the pandemic – predicts that the trend will finally even out this year, as labor shortages abate and more people gradually return to offices. (Klotz cites the potential for a recession, which will potentially force some people to return to jobs they were maybe happy to have left, as a major factor.)

But while most charts, including data from the US Bureau of Labor Statistics, show the resignation trend becoming more “muted,” there are signs that the Great Resignation may still be influencing overall decision-making on both sides of the employee-employer divide. According to HR Digest, companies that invested in employee development and efforts to attract and keep talent saw a 58% increase in employee retention in 2022. On a recent LinkedIn survey, 61% of US employees said they were considering resigning from their jobs in 2023.

In the aggregate, it’s probably too soon to tell whether or not the pandemic and Great Recession were a blip on the labor market radar or a significant milestone event that with any kind of real long-term impact.

SoundCloud’s Attempt at a Revamp? An AI-Driven Recommendation Feed

Kristin Snyder

Kristin Snyder is dot.LA's 2022/23 Editorial Fellow. She previously interned with Tiger Oak Media and led the arts section for UCLA's Daily Bruin.

SoundCloud’s Attempt at a Revamp? An AI-Driven Recommendation Feed
Photo by C D-X on Unsplash

AI has infiltrated just about every creative field. Poets have complained about the tech’s shoddy imitations of famous writers, anime fans can watch an unending AI-generated show and artists are suing an AI company over copyright usage. The music industry is no exception.

Though there are plenty of examples of people using ChatGPT to write songs, AI has been most successfully implemented as a way for music platforms to recommend music.

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https://twitter.com/ksnyder_db

Behind Her Empire: Gobble Founder and CEO Ooshma Garg On Finding Product Market Fit

Decerry Donato

Decerry Donato is a reporter at dot.LA. Prior to that, she was an editorial fellow at the company. Decerry received her bachelor's degree in literary journalism from the University of California, Irvine. She continues to write stories to inform the community about issues or events that take place in the L.A. area. On the weekends, she can be found hiking in the Angeles National forest or sifting through racks at your local thrift store.

Behind Her Empire: Gobble Founder and CEO Ooshma Garg On Finding Product Market Fit
Courtesy of Behind Her Empire

On this episode of Behind Her Empire, Gobble Founder and CEO Ooshma Garg discusses raising capital for her company and her ever-evolving business model.


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