How UCLA-Backed Biotech Firm Avenda Health is Using AI to Map Cancer Tumors

Samson Amore

Samson Amore is a reporter for dot.LA. He holds a degree in journalism from Emerson College. Send tips or pitches to samsonamore@dot.la and find him on Twitter @Samsonamore.

How UCLA-Backed Biotech Firm Avenda Health is Using AI to Map Cancer Tumors
Avenda Health

Last year, the Massachusetts Institute of Technology began testing an artificial intelligence platform called Tempo that used a risk-assessment algorithm to recommend mammogram screenings. By feeding the AI personal health data, including risk factors, existing diagnoses and prior screening information, Tempo was able to recommend to clinicians when to schedule exams for breast cancer.


The algorithm was an early example of the push to use bots to screen for and detect cancers. More recently, Avenda Health, a Culver City-based biotech firm, announced the development of a platform called Unfold AI—a breakthrough device that uses AI to create maps of prostate cancer tumors. The technology works by using machine learning to analyze existing patient health information to create a digital map of where prostate tumors reside, with the goal of using that imaging to better administer life-saving surgeries to patients.

Currently, the mapping is done via MRI. While MRIs do work, Avenda Health co-founder Dr. Shyam Natarajan claimed Unfold AI’s imaging is more comprehensive, adding that with MRIs you can only see “only 39% of finding all the cancer, we’re boosting that to 97%.”

To develop the device, Avenda partnered with Bioscience LA, a nonprofit that was founded by the city of Los Angeles in 2018 to foster growth in the region’s bioscience industries and backed by some of Southern California’s biggest healthcare providers and biopharmaceutical companies including Amgen, Cedars-Sinai and City of Hope.

In addition, the FDA announced a “breakthrough device” designation to allow Avenda to begin testing the products on patients.

Natarajan co-founded Avenda Health in 2017 alongside Dr. Brit Berry-Pusey and Dr. Leonard Marks as a spinout of UCLA. The company has raised $16 million to date, including a grant from the National Cancer Institute and a $10 million Series B last June. Avenda recently announced it will expand its space at the Bioscience LA incubator, with its roughly 18 employees occupying 2,200 square feet in BioscienceLA’s Culver City headquarters.

According to the U.S. Centers for Disease Control and Prevention, prostate cancer is the second most common cancer among men in the U.S. In 2019, the disease affected an estimated 21,769 men in California alone. The problem Avenda is trying to solve in part is that most men don’t get screened for prostate cancer because they either aren’t aware of the need or are concerned about the intrusiveness of getting an exam.

More importantly, Natarajan hopes the device can help with the invasiveness of prostate surgery as well. While it doesn’t perform surgeries, Unfold AI does create detailed imaging of a prostate cancer tumor, which allows surgeons to more specifically pinpoint what to remove.

He likened current prostate cancer treatments to cutting your whole hand off if you noticed a mole on it. “Even though one out of every seven or eight men have a lifetime risk of getting this disease, about 50% or more of men end up losing their quality of life, their sexual and urinary function, and sometimes bowel function as a result of treatments.”

In those cases, removing cancer cells opens the door to a new kind of physical torture. “We do a really good job of screening patients and selecting them for risk of prostate cancer,” said Natarajan. “[But] we have not done a great job of correctly stratifying who's actually going to be benefiting from therapy and who is going to benefit from that preservation of quality of life from a localized treatment that doesn’t need to treat the entire cancer or the entire gland."

Unfold AI won’t prevent prostate cancer, certainly. But, Natarajan added, “It’s a leap forward in how we're able to actually identify patients with prostate cancer and their tumors. To really inform better decisions for therapy and to give a better target for physicians to go and take out the cancer while leaving those critical structures that control quality of life, intact.”

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⏳Top Productivity Techniques for Entrepreneurs

In the busy world of entrepreneurship, staying productive is crucial for achieving success. With numerous tasks (and social media) competing for your attention, it can be tough to stay organized and focused. Fortunately, several proven productivity hacks can help you manage your time effectively and prioritize your workload. These strategies are backed by research and have been used by successful individuals in various fields. In this listicle, we’ll explore five effective productivity hacks, including the Pomodoro Technique and the Eisenhower Matrix, that can improve your work habits and enhance your entrepreneurial efforts.


The Pomodoro Technique

Developed by Francesco Cirillo in the late 1980s, the Pomodoro Technique uses a kitchen timer to break work into intervals, typically 25 minutes long, followed by short breaks. Cirillo named the method after the tomato-shaped timer he used as a university student, and it has since been adopted by many professionals and students to enhance focus and productivity. To implement it:

  • Choose a task to work on
  • Set a timer for 25 minutes
  • Work on the task until the timer rings
  • Take a short 5-minute break
  • After 4 pomodoros, take a longer 15-30 minute break

The Eisenhower Matrix

Named after former U.S. President Dwight D. Eisenhower, this prioritization method helps individuals categorize tasks based on urgency and importance. Eisenhower famously stated, "What is important is seldom urgent and what is urgent is seldom important," which underscores the value of distinguishing between these two aspects to effectively manage time and tasks. This prioritization method helps you focus on what's truly important by categorizing tasks into four quadrants based on urgency and importance:

  1. Urgent and important: Do immediately
  2. Important but not urgent: Schedule for later
  3. Urgent but not important: Delegate if possible
  4. Neither urgent nor important: Eliminate

Time Blocking

Time blocking is a technique used by many successful entrepreneurs, including Jack Dorsey and Cal Newport, to allocate specific periods for different types of work. By scheduling tasks in advance, individuals can minimize distractions and ensure they dedicate focused time to their most important responsibilities. This creates structure and helps minimize context switching. For example:

  1. 9-11 AM: Deep work on top priority project
  2. 11 AM-12 PM: Respond to emails/messages
  3. 1-3 PM: Meetings
  4. 3-5 PM: Administrative tasks

The Two-Minute Rule

Popularized by productivity expert David Allen in his book "Getting Things Done," the Two-Minute Rule states that if a task can be completed in two minutes or less, you should do it immediately. This approach helps prevent small tasks from piling up and cluttering your to-do list, allowing for a more organized workflow.


Batching Similar Tasks

Batching tasks is a technique used by many high-performing individuals, including writer Tim Ferriss, who advocates for grouping similar activities to minimize context switching. By focusing on one type of task at a time, such as responding to emails or making phone calls, you can increase efficiency and reduce mental fatigue.


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LA Startups Supercharging Cars and Dating 🚗⚡💑

🔦 Spotlight

Happy Friday Los Angeles!

EVgo Inc., a leading Electric Vehicle (EV) charging company based in West Los Angeles, has seen substantial growth under CEO Badar Khan. The company now operates over 3,400 fast chargers across 1,000 sites nationwide, strategically placed in high-traffic urban and suburban areas to enhance convenience for EV users. EVgo’s model focuses on owning and managing its charging stations to ensure a seamless experience, reflecting its commitment to supporting the mass adoption of electric vehicles and facilitating the transition to cleaner transportation.

In a different electrifying market, Joe Feminella, inspired by his own successful dating journey, launched the dating app, First Round’s On Me in El Segundo with $5 million in funding. This app differentiates itself by requiring users to schedule a date within 24 hours of matching, and after a soft launch in select markets, it expanded nationwide in 2024. As the dating app market faces criticism over algorithmic practices and premium features, First Round’s On Me aims to offer a more genuine and immediate dating experience. Both EVgo and First Round’s On Me exemplify how companies in different industries are addressing their respective market challenges with innovative approaches to improve user experience and engagement.


🤝 Venture Deals

LA Companies

  • 3DEO, a startup that specializes in 3D printing small, high-volume metal parts, raised a $3.5M Strategic Investment Round from Mizuhio Bank. - learn more
  • Spotter, a startup that underwrites creators and offers AI tools, raised a $7.4M Funding Round. - learn more
  • Cashmere, a lead generation startup for wealth managers, raised a $3.6M Seed Round. Canapi Ventures led, and was joined by Benchstrength, Plug and Play, The House Fund, and Courtyard Ventures. - learn more

LA Venture Funds

  • Crosscut Ventures participated in an $8.9M Series A Extension for Nostra AI, a startup that helps e-commerce businesses improve their website performance by speeding up load times. - learn more
  • Fika Ventures, an eight-year-old Los Angeles venture capital firm, has raised a fourth fund in the amount of $160 million to invest in early-stage B2B startups. - learn more

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      🍵☕️Top 6 Coffee Alternatives for Enhanced Productivity

      In the fast-paced world of startups and venture capital in Los Angeles, maintaining peak productivity is essential for founders and investors alike. As the hustle intensifies, many are seeking alternatives to traditional coffee that not only provide a sustained energy boost but also support overall health and well-being. The following list highlights some of the top-rated coffee alternatives that can enhance focus and productivity while minimizing the adverse effects of caffeine. These options incorporate adaptogens, superfoods, and gut-friendly ingredients, making them ideal choices for those looking to optimize their performance without the afternoon crash.


      Matcha

      Image Source: Jade Leaf Matcha

      Matcha is a finely ground green tea that offers a moderate amount of caffeine, along with L-theanine, which promotes relaxation without drowsiness. This combination can enhance focus and concentration, making matcha a suitable alternative for those looking to boost productivity without the jitters of coffee.

      Popular Brands: ReNude Chaga Matcha (60 mg caffeine), Golde Pure Matcha (60 mg caffeine), Organic Ceremonial Matcha - Teahouse Edition (30 mg caffeine)


      Dandelion Root Coffee

      Image Source: Amazon

      Dandelion root coffee is a caffeine-free alternative that mimics the taste of coffee. It is known for its potential to support liver health and digestion, which can contribute to overall well-being and productivity. The drink can help avoid the acidity and jitters that often accompany regular coffee, making it a gentler option for those sensitive to caffeine.

      Popular Brands: Dandy Blend (0 mg caffeine), Teeccino Dandelion Dark Roast (0 mg caffeine)


      Adaptogenic Drinks

      Image Source: MUD\WTR Masala Chai

      Adaptogenic beverages, which include ingredients like ashwagandha, reishi, and maca, are designed to help the body adapt to stress and promote mental clarity. These drinks can provide a sustained energy boost without the crash, supporting productivity throughout the day. They are often made with superfoods and spices that enhance both physical and mental performance.

      Popular Brands: MUD\WTR Masala Chai (35 mg caffeine), Four Sigmatic Think Coffee (150 mg caffeine), ReNude Chagaccino (0 mg caffeine)


      Golden Milk (Turmeric Latte)

      Image Source: Golde

      Golden milk, made from turmeric, ginger, and milk (or a milk alternative), is a caffeine-free option that can improve mood and reduce inflammation. The calming properties of this drink can help maintain focus and clarity, making it a great addition to a productive morning routine.

      Popular Brands: Golde Turmeric Latte Blend (0 mg caffeine), Blume Turmeric Blend (0 mg caffeine), Four Sigmatic Golden Latte Mix (0 mg caffeine)



      Chicory Root Coffee

      Image Source: Teeccino

      Chicory root coffee is an excellent alternative that satisfies the desire for a warm beverage without caffeine. It is rich in inulin, a prebiotic fiber that aids in digestion and promotes gut health by supporting beneficial bacteria. Chicory coffee has a nutty, earthy flavor and can help control blood sugar levels, contributing to overall energy and productivity throughout the day.

      Popular Brands: Anthony’s Instant Chicory Root (0 mg caffeine), Teeccino Chicory Coffee Alternative (0 mg caffeine)


      Yerba Mate

      Image Source: Guayaki Yerba Mate

      Yerba mate is a traditional South American herbal tea made from the leaves of the Ilex paraguariensis plant. It contains about 40-80 mg of caffeine per serving, which is less than a standard cup of coffee but enough to provide a gentle energy boost. Yerba mate is rich in antioxidants, vitamins, and minerals, and users often report feeling energized without the jitters or crashes associated with coffee. It has a unique, slightly bitter flavor and can be enjoyed in various forms, including loose-leaf tea and pre-brewed options.

      Popular Brands: Guayaki Yerba Mate (40-150 mg caffeine)


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