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XAcelyrin Wants to Move LA Biotech Beyond the 'Innovate and Exit' Model
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
The reality for most bioscience startups developing drugs is that, if they don't fail, they will be swallowed up by a pharmaceutical giant.
After a decade in the pharmaceutical industry and being involved in developing several high-profile drugs including Humira, Shao-Lee Lin wasn't interested in creating another company for big pharma. She wanted to create the next Amgen.
She created Acelyrin with biotech veteran Bob Carey last year to develop immunological drugs. They announced their first drug in development is izokibep; a high-potency, small molecular drug that aims to target several autoimmune diseases like axial spondyloarthritis, an arthritis that affects the spine; and hidradenitis suppurativa, a painful chronic disease. More than 300 patients have been dosed with it.
"We're not looking to be the typical startup company that ultimately will incubate something for a number of years and flip and exit and then cycle back and do it again," she said.
Lin moved from Chicago to Southern California after getting the backing of Westlake Village BioPartners, a venture firm co-founded by ex-Amgen executives Sean Harper and Beth Seidenberg.
"Part of our mission was to build the L.A. biotech hub," Lin said. "I was living in the Chicago area at the time and I agreed to relocate here and to headquarter Acelyrin here as part of [Westlake Village BioPartners] efforts to continue to build the L.A. biotech hub."
Now, the company has announced $250 million in Series B funding led by AyurMaya, Surveyor Capital and Westlake Village BioPartners. Acelyrin's $250 million raise will go towards further developing izokibep to get it in the hands of patients, and creating new drugs.
"It's this $250 million Series B that just makes it that much more real, tangible and vibrant for us, that enables us to continue to attract innovators and talent in the area, as well as enhance the opportunities of all of those people who are already in the area."
Westlake Village BioPartners launched in 2018 with several million dollars to invest in Southern California bioscience startups on the frontier of drug development. It opened a 130,000 square foot campus next to Amgen's headquarters to house many of the startups they invest in.
Lin spent more than a decade at biopharma giants like Amgen, Gilead and Abbvie and had a hand in several drugs like Humira and Enbrel.
"We really are after building a long-term sustainable biopharma company that ultimately has fully integrated R&D as well as commercialization," Lin said.
- Biotech in Los Angeles Might Soon Get Its Own Bioscience Hub - dot ... ›
- Peter Calveley Named New COO at Westlake Village BioPartners ... ›
- Venture Capital Firm Westlake Village BioPartners Raises $500M ›
- Acelyrin Biopharma Startup Looking for Immunotherapy Drugs - dot.LA ›
- Terray Therapeutics Raises $60M to Speed Up Drug Discovery - dot.LA ›
Keerthi Vedantam is a bioscience reporter at dot.LA. She cut her teeth covering everything from cloud computing to 5G in San Francisco and Seattle. Before she covered tech, Keerthi reported on tribal lands and congressional policy in Washington, D.C. Connect with her on Twitter, Clubhouse (@keerthivedantam) or Signal at 408-470-0776.
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Snap Says It Will Miss Earnings Targets, Slow Down Hiring
Christian Hetrick is dot.LA's Entertainment Tech Reporter. He was formerly a business reporter for the Philadelphia Inquirer and reported on New Jersey politics for the Observer and the Press of Atlantic City.
Snap warned on Monday that it will likely report lower-than-expected revenues and profits this quarter—a revelation that sent the social media firm’s stock price plunging by 30%.
“The macroeconomic environment has deteriorated further and faster than anticipated,” Snap disclosed in a filing with the Securities and Exchange Commission. “As a result, we believe it is likely that we will report revenue and adjusted EBITDA below the low end of our [second quarter] 2022 guidance range.”
The Santa Monica-based company was already bracing for another challenging quarter due to economic headwinds like inflation and Russia’s invasion of Ukraine, which it said have harmed the digital advertising market. Snap, which generates virtually all of its revenue from ads, is also still grappling with Apple’s decision to restrict how users are tracked on mobile devices.
As a result of the gloomy outlook, Snap is set to slow down on hiring. The company now plans to hire another 500 new employees through the end of this year, compared to the 900 employees who have already accepted offers this year and the 2,000 people it added over the last 12 months, according to The Verge, which cited a memo from Snap CEO Evan Spiegel.
“Our most meaningful gains over the coming months will come as a result of improved productivity from our existing team members,” Spiegel wrote in his note to staff.
Snap’s shares subsequently fell more than 30% in after-hours trading, to $15.71 as of 4:45 p.m. Pacific Time. The company’s stock closed Monday’s trading at $22.47—down 52% since the start of this year and 73% off its 52-week high in September. (Disclosure: Snap is an investor in dot.LA.)
Christian Hetrick is dot.LA's Entertainment Tech Reporter. He was formerly a business reporter for the Philadelphia Inquirer and reported on New Jersey politics for the Observer and the Press of Atlantic City.
Halsey Blasts Record Label for ‘Fake Viral’ TikTok Requirement
Kristin Snyder is an editorial intern for dot.la. She previously interned with Tiger Oak Media and led the arts section for UCLA's Daily Bruin.
The singer Halsey has claimed that their record label is requiring TikTok momentum before letting them release new music, in comments that draw attention to the video-sharing app’s growing influence over the music industry.
In a TikTok video released Sunday, Halsey claimed the Astralwerks-Capitol label will not allow them to release their latest song until “they can fake a viral moment on TikTok.” Halsey played the song in the background as they said that “basically every artist these days” is stuck waiting for TikTok virality as they plan music releases. In a subsequent series of Tweets, Halsey said that their TikTok video ironically going viral has not yet resulted in a release date, despite the song having been ready for a month.
The response has ranged from people viewing the video as a disingenuous marketing scheme meant to gain sympathy to others expressing support for the musician.
“Our belief in Halsey as a singular and important artist is total and unwavering,” an Astralwerks-Capitol rep told Variety. “We can’t wait for the world to hear their brilliant new music.”
Other musicians have recently expressed similar complaints. Ahead of Adele’s 2021 album, the singer said she shot down her team’s request to share her new music on TikTok. But few in the industry have Adele’s reach, and artists like Florence Welch, Ed Sheeran and FKA Twigs have all taken to TikTok at their labels' behest.
In April, Lizzo released her latest single “About Damn Time” on TikTok with an accompanying dance; the audio has since been used in over 1 million videos on the app, while the song made it to no. 9 on the Billboard Hot 100 chart. Other music artists are using TikTok stars to promote their material, with singer Harry Styles tapping influencer Brittany Broski to take over his social media ahead of his recent concert.
As artists can now grow their audiences on social media without relying on traditional mainstream media, it’s clear that TikTok has disrupted the industry. Take Lil Nas X, who used the app to promote "Old Town Road" and was up for five Grammy awards this year. On occasion, a short singing clip can even lead labels to sign new artists, as was the case with Australian singer Peach PRC.
A viral moment on TikTok can also take an unknown song or music project to new heights. “The Unofficial Bridgerton Musical,” a passion project started on the platform, beat theater legend Andrew Lloyd Webber to take home a Grammy earlier this year. Having bought the rights to Universal Music Group’s catalog and launched a platform that would allow artists to monetize their music uploaded to the app, TikTok is certainly leaning into its industry impact.
Kristin Snyder is an editorial intern for dot.la. She previously interned with Tiger Oak Media and led the arts section for UCLA's Daily Bruin.
Activision Blizzard Workers Win Union Vote
Samson Amore is a reporter for dot.LA. He previously covered technology and entertainment for TheWrap and reported on the SoCal startup scene for the Los Angeles Business Journal. Samson is also a proud member of the Transgender Journalists Association. Send tips or pitches to samsonamore@dot.la and find him on Twitter at @Samsonamore. Pronouns: he/him
Workers at Activision Blizzard subsidiary Raven Software won their labor union vote today—a move that certifies the first union at a major video game publisher in the U.S., and one that could potentially transform the Santa Monica-based game developer that Microsoft is paying $69 billion to acquire.
Twenty-two employees at Wisconsin-based Raven voted 19-to-3 in favor of ratifying their Game Workers Alliance union in a National Labor Relations Board-sponsored election on Monday. The Raven workers—who do quality assurance testing for popular Activision titles like “Call of Duty”—formed the Game Workers Alliance in January and proceeded with the vote after Activision refused to voluntarily recognize the union.
The vote marks the first time that employees at a AAA game publisher in the U.S. have successfully unionized their workplace. It could also be a key step toward unionizing the rest of Activision’s 10,000-person workforce—something that Raven labor organizers told dot.LA earlier this year is part of their larger plan.
“We respect and believe in the right of all employees to decide whether or not to support or vote for a union,” Activision spokesperson Talia Ron told dot.LA in an email Monday. “We believe that an important decision that will impact the entire Raven Software studio of roughly 350 people should not be made by 19 Raven employees.”
None of Activision’s major competitors, such as West Los Angeles-based Riot Games, have unionized employees. Across the entire video game industry, only indie studio Vodeo Games has a labor union—one which became the first certified game workers’ union in North America last year.
“This is a huge win for not only the gaming industry but AAA gaming, because this is the first studio you're seeing out of a AAA [publisher] actually unionizing,” labor organizer and former Activision quality assurance tester Jessica Gonazlez told dot.LA.
Pro-union Activision employees have long felt that an organized workplace could provide the muscle they need to address issues that have plagued the company and their industry at large—from long, grueling work hours to sexual harassment and discrimination. “I'm very, very hopeful that this is going to be part of a larger wave of unionizing in the video game industry as a whole,” Gonzalez added.
While Microsoft executives have said that the Seattle tech giant won’t stand in the way of union efforts at Activision, the game developer has taken steps perceived as anti-union among its workers—such as leaving Raven Software employees out of a pay bump for quality assurance testers and proposing contract language that would prevent workers from organizing. Raven workers began organizing after walking off the job in December in protest of Activision’s decision to lay off 12 quality assurance contractors.
In a statement, Sara Steffens, secretary-treasurer for the Communications Workers of America labor union backing Raven’s Game Workers Alliance, said “Activision did everything it could, including breaking the law, to try to prevent the Raven QA workers from forming their union.”
“Quality assurance workers at Raven Software are bringing much-needed change to Activision and to the video game industry,” Steffens said. “At this critical time for the company and its employees, these workers will soon have an enforceable union contract and a voice on the job.”
- Labor Union Urges SEC to Investigate Activision Over Filing - dot.LA ›
- Activision Leaves Union Workers Out of Game Testers' Pay Raise ... ›
- Microsoft Says It Won't Block Activision Labor Unions - dot.LA ›
Samson Amore is a reporter for dot.LA. He previously covered technology and entertainment for TheWrap and reported on the SoCal startup scene for the Los Angeles Business Journal. Samson is also a proud member of the Transgender Journalists Association. Send tips or pitches to samsonamore@dot.la and find him on Twitter at @Samsonamore. Pronouns: he/him